format of significance of the study in research

How To Write Significance of the Study (With Examples) 

Whether you’re writing a research paper or thesis, a portion called Significance of the Study ensures your readers understand the impact of your work. Learn how to effectively write this vital part of your research paper or thesis through our detailed steps, guidelines, and examples.

Related: How to Write a Concept Paper for Academic Research

Table of Contents

What is the significance of the study.

The Significance of the Study presents the importance of your research. It allows you to prove the study’s impact on your field of research, the new knowledge it contributes, and the people who will benefit from it.

Related: How To Write Scope and Delimitation of a Research Paper (With Examples)

Where Should I Put the Significance of the Study?

The Significance of the Study is part of the first chapter or the Introduction. It comes after the research’s rationale, problem statement, and hypothesis.

Related: How to Make Conceptual Framework (with Examples and Templates)

Why Should I Include the Significance of the Study?

The purpose of the Significance of the Study is to give you space to explain to your readers how exactly your research will be contributing to the literature of the field you are studying 1 . It’s where you explain why your research is worth conducting and its significance to the community, the people, and various institutions.

How To Write Significance of the Study: 5 Steps

Below are the steps and guidelines for writing your research’s Significance of the Study.

1. Use Your Research Problem as a Starting Point

Your problem statement can provide clues to your research study’s outcome and who will benefit from it 2 .

Ask yourself, “How will the answers to my research problem be beneficial?”. In this manner, you will know how valuable it is to conduct your study. 

Let’s say your research problem is “What is the level of effectiveness of the lemongrass (Cymbopogon citratus) in lowering the blood glucose level of Swiss mice (Mus musculus)?”

Discovering a positive correlation between the use of lemongrass and lower blood glucose level may lead to the following results:

• Increased public understanding of the plant’s medical properties;
• Higher appreciation of the importance of lemongrass  by the community;
• Adoption of lemongrass tea as a cheap, readily available, and natural remedy to lower their blood glucose level.

Once you’ve zeroed in on the general benefits of your study, it’s time to break it down into specific beneficiaries.

2. State How Your Research Will Contribute to the Existing Literature in the Field

Think of the things that were not explored by previous studies. Then, write how your research tackles those unexplored areas. Through this, you can convince your readers that you are studying something new and adding value to the field.

3. Explain How Your Research Will Benefit Society

In this part, tell how your research will impact society. Think of how the results of your study will change something in your community. 

For example, in the study about using lemongrass tea to lower blood glucose levels, you may indicate that through your research, the community will realize the significance of lemongrass and other herbal plants. As a result, the community will be encouraged to promote the cultivation and use of medicinal plants.

4. Mention the Specific Persons or Institutions Who Will Benefit From Your Study

Using the same example above, you may indicate that this research’s results will benefit those seeking an alternative supplement to prevent high blood glucose levels.

5. Indicate How Your Study May Help Future Studies in the Field

You must also specifically indicate how your research will be part of the literature of your field and how it will benefit future researchers. In our example above, you may indicate that through the data and analysis your research will provide, future researchers may explore other capabilities of herbal plants in preventing different diseases.

Tips and Warnings

• Think ahead . By visualizing your study in its complete form, it will be easier for you to connect the dots and identify the beneficiaries of your research.
• Write concisely. Make it straightforward, clear, and easy to understand so that the readers will appreciate the benefits of your research. Avoid making it too long and wordy.
• Go from general to specific . Like an inverted pyramid, you start from above by discussing the general contribution of your study and become more specific as you go along. For instance, if your research is about the effect of remote learning setup on the mental health of college students of a specific university , you may start by discussing the benefits of the research to society, to the educational institution, to the learning facilitators, and finally, to the students.
• Seek help . For example, you may ask your research adviser for insights on how your research may contribute to the existing literature. If you ask the right questions, your research adviser can point you in the right direction.
• Revise, revise, revise. Be ready to apply necessary changes to your research on the fly. Unexpected things require adaptability, whether it’s the respondents or variables involved in your study. There’s always room for improvement, so never assume your work is done until you have reached the finish line.

Significance of the Study Examples

This section presents examples of the Significance of the Study using the steps and guidelines presented above.

Example 1: STEM-Related Research

Research Topic: Level of Effectiveness of the Lemongrass ( Cymbopogon citratus ) Tea in Lowering the Blood Glucose Level of Swiss Mice ( Mus musculus ).

Significance of the Study .

This research will provide new insights into the medicinal benefit of lemongrass ( Cymbopogon citratus ), specifically on its hypoglycemic ability.

Through this research, the community will further realize promoting medicinal plants, especially lemongrass, as a preventive measure against various diseases. People and medical institutions may also consider lemongrass tea as an alternative supplement against hyperglycemia. 

Moreover, the analysis presented in this study will convey valuable information for future research exploring the medicinal benefits of lemongrass and other medicinal plants.  

Example 2: Business and Management-Related Research

Research Topic: A Comparative Analysis of Traditional and Social Media Marketing of Small Clothing Enterprises.

Significance of the Study:

By comparing the two marketing strategies presented by this research, there will be an expansion on the current understanding of the firms on these marketing strategies in terms of cost, acceptability, and sustainability. This study presents these marketing strategies for small clothing enterprises, giving them insights into which method is more appropriate and valuable for them. 

Specifically, this research will benefit start-up clothing enterprises in deciding which marketing strategy they should employ. Long-time clothing enterprises may also consider the result of this research to review their current marketing strategy.

Furthermore, a detailed presentation on the comparison of the marketing strategies involved in this research may serve as a tool for further studies to innovate the current method employed in the clothing Industry.

Example 3: Social Science -Related Research.

Research Topic:  Divide Et Impera : An Overview of How the Divide-and-Conquer Strategy Prevailed on Philippine Political History.

Significance of the Study :

Through the comprehensive exploration of this study on Philippine political history, the influence of the Divide et Impera, or political decentralization, on the political discernment across the history of the Philippines will be unraveled, emphasized, and scrutinized. Moreover, this research will elucidate how this principle prevailed until the current political theatre of the Philippines.

In this regard, this study will give awareness to society on how this principle might affect the current political context. Moreover, through the analysis made by this study, political entities and institutions will have a new approach to how to deal with this principle by learning about its influence in the past.

In addition, the overview presented in this research will push for new paradigms, which will be helpful for future discussion of the Divide et Impera principle and may lead to a more in-depth analysis.

Example 4: Humanities-Related Research

Research Topic: Effectiveness of Meditation on Reducing the Anxiety Levels of College Students.

Significance of the Study: 

This research will provide new perspectives in approaching anxiety issues of college students through meditation. 

Specifically, this research will benefit the following:

 Community – this study spreads awareness on recognizing anxiety as a mental health concern and how meditation can be a valuable approach to alleviating it.

Academic Institutions and Administrators – through this research, educational institutions and administrators may promote programs and advocacies regarding meditation to help students deal with their anxiety issues.

Mental health advocates – the result of this research will provide valuable information for the advocates to further their campaign on spreading awareness on dealing with various mental health issues, including anxiety, and how to stop stigmatizing those with mental health disorders.

Parents – this research may convince parents to consider programs involving meditation that may help the students deal with their anxiety issues.

Students will benefit directly from this research as its findings may encourage them to consider meditation to lower anxiety levels.

Future researchers – this study covers information involving meditation as an approach to reducing anxiety levels. Thus, the result of this study can be used for future discussions on the capabilities of meditation in alleviating other mental health concerns.

Frequently Asked Questions

1. what is the difference between the significance of the study and the rationale of the study.

Both aim to justify the conduct of the research. However, the Significance of the Study focuses on the specific benefits of your research in the field, society, and various people and institutions. On the other hand, the Rationale of the Study gives context on why the researcher initiated the conduct of the study.

Let’s take the research about the Effectiveness of Meditation in Reducing Anxiety Levels of College Students as an example. Suppose you are writing about the Significance of the Study. In that case, you must explain how your research will help society, the academic institution, and students deal with anxiety issues through meditation. Meanwhile, for the Rationale of the Study, you may state that due to the prevalence of anxiety attacks among college students, you’ve decided to make it the focal point of your research work.

2. What is the difference between Justification and the Significance of the Study?

In Justification, you express the logical reasoning behind the conduct of the study. On the other hand, the Significance of the Study aims to present to your readers the specific benefits your research will contribute to the field you are studying, community, people, and institutions.

Suppose again that your research is about the Effectiveness of Meditation in Reducing the Anxiety Levels of College Students. Suppose you are writing the Significance of the Study. In that case, you may state that your research will provide new insights and evidence regarding meditation’s ability to reduce college students’ anxiety levels. Meanwhile, you may note in the Justification that studies are saying how people used meditation in dealing with their mental health concerns. You may also indicate how meditation is a feasible approach to managing anxiety using the analysis presented by previous literature.

3. How should I start my research’s Significance of the Study section?

– This research will contribute… – The findings of this research… – This study aims to… – This study will provide… – Through the analysis presented in this study… – This study will benefit…

Moreover, you may start the Significance of the Study by elaborating on the contribution of your research in the field you are studying.

4. What is the difference between the Purpose of the Study and the Significance of the Study?

The Purpose of the Study focuses on why your research was conducted, while the Significance of the Study tells how the results of your research will benefit anyone.

Suppose your research is about the Effectiveness of Lemongrass Tea in Lowering the Blood Glucose Level of Swiss Mice . You may include in your Significance of the Study that the research results will provide new information and analysis on the medical ability of lemongrass to solve hyperglycemia. Meanwhile, you may include in your Purpose of the Study that your research wants to provide a cheaper and natural way to lower blood glucose levels since commercial supplements are expensive.

5. What is the Significance of the Study in Tagalog?

In Filipino research, the Significance of the Study is referred to as Kahalagahan ng Pag-aaral.

• Draft your Significance of the Study. Retrieved 18 April 2021, from http://dissertationedd.usc.edu/draft-your-significance-of-the-study.html
• Regoniel, P. (2015). Two Tips on How to Write the Significance of the Study. Retrieved 18 April 2021, from https://simplyeducate.me/2015/02/09/significance-of-the-study/

Written by Jewel Kyle Fabula

in Career and Education , Juander How

Jewel Kyle Fabula

Jewel Kyle Fabula is a Bachelor of Science in Economics student at the University of the Philippines Diliman. His passion for learning mathematics developed as he competed in some mathematics competitions during his Junior High School years. He loves cats, playing video games, and listening to music.

Browse all articles written by Jewel Kyle Fabula

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The Savvy Scientist

Experiences of a London PhD student and beyond

What is the Significance of a Study? Examples and Guide

If you’re reading this post you’re probably wondering: what is the significance of a study?

No matter where you’re at with a piece of research, it is a good idea to think about the potential significance of your work. And sometimes you’ll have to explicitly write a statement of significance in your papers, it addition to it forming part of your thesis.

In this post I’ll cover what the significance of a study is, how to measure it, how to describe it with examples and add in some of my own experiences having now worked in research for over nine years.

If you’re reading this because you’re writing up your first paper, welcome! You may also like my how-to guide for all aspects of writing your first research paper .

Looking for guidance on writing the statement of significance for a paper or thesis? Click here to skip straight to that section.

What is the Significance of a Study?

For research papers, theses or dissertations it’s common to explicitly write a section describing the significance of the study. We’ll come onto what to include in that section in just a moment.

However the significance of a study can actually refer to several different things.

Working our way from the most technical to the broadest, depending on the context, the significance of a study may refer to:

• Within your study: Statistical significance. Can we trust the findings?
• Wider research field: Research significance. How does your study progress the field?
• Commercial / economic significance: Could there be business opportunities for your findings?
• Societal significance: What impact could your study have on the wider society.
• And probably other domain-specific significance!

We’ll shortly cover each of them in turn, including how they’re measured and some examples for each type of study significance.

But first, let’s touch on why you should consider the significance of your research at an early stage.

Why Care About the Significance of a Study?

No matter what is motivating you to carry out your research, it is sensible to think about the potential significance of your work. In the broadest sense this asks, how does the study contribute to the world?

After all, for many people research is only worth doing if it will result in some expected significance. For the vast majority of us our studies won’t be significant enough to reach the evening news, but most studies will help to enhance knowledge in a particular field and when research has at least some significance it makes for a far more fulfilling longterm pursuit.

Furthermore, a lot of us are carrying out research funded by the public. It therefore makes sense to keep an eye on what benefits the work could bring to the wider community.

Often in research you’ll come to a crossroads where you must decide which path of research to pursue. Thinking about the potential benefits of a strand of research can be useful for deciding how to spend your time, money and resources.

It’s worth noting though, that not all research activities have to work towards obvious significance. This is especially true while you’re a PhD student, where you’re figuring out what you enjoy and may simply be looking for an opportunity to learn a new skill.

However, if you’re trying to decide between two potential projects, it can be useful to weigh up the potential significance of each.

Let’s now dive into the different types of significance, starting with research significance.

Research Significance

What is the research significance of a study.

Unless someone specifies which type of significance they’re referring to, it is fair to assume that they want to know about the research significance of your study.

Research significance describes how your work has contributed to the field, how it could inform future studies and progress research.

Where should I write about my study’s significance in my thesis?

Typically you should write about your study’s significance in the Introduction and Conclusions sections of your thesis.

It’s important to mention it in the Introduction so that the relevance of your work and the potential impact and benefits it could have on the field are immediately apparent. Explaining why your work matters will help to engage readers (and examiners!) early on.

It’s also a good idea to detail the study’s significance in your Conclusions section. This adds weight to your findings and helps explain what your study contributes to the field.

On occasion you may also choose to include a brief description in your Abstract.

What is expected when submitting an article to a journal

It is common for journals to request a statement of significance, although this can sometimes be called other things such as:

• Impact statement
• Significance statement
• Advances in knowledge section

Here is one such example of what is expected:

Impact Statement:  An Impact Statement is required for all submissions.  Your impact statement will be evaluated by the Editor-in-Chief, Global Editors, and appropriate Associate Editor. For your manuscript to receive full review, the editors must be convinced that it is an important advance in for the field. The Impact Statement is not a restating of the abstract. It should address the following: Why is the work submitted important to the field? How does the work submitted advance the field? What new information does this work impart to the field? How does this new information impact the field? Experimental Biology and Medicine journal, author guidelines

Typically the impact statement will be shorter than the Abstract, around 150 words.

Defining the study’s significance is helpful not just for the impact statement (if the journal asks for one) but also for building a more compelling argument throughout your submission. For instance, usually you’ll start the Discussion section of a paper by highlighting the research significance of your work. You’ll also include a short description in your Abstract too.

How to describe the research significance of a study, with examples

Whether you’re writing a thesis or a journal article, the approach to writing about the significance of a study are broadly the same.

I’d therefore suggest using the questions above as a starting point to base your statements on.

• Why is the work submitted important to the field?
• How does the work submitted advance the field?
• What new information does this work impart to the field?
• How does this new information impact the field?

Answer those questions and you’ll have a much clearer idea of the research significance of your work.

When describing it, try to clearly state what is novel about your study’s contribution to the literature. Then go on to discuss what impact it could have on progressing the field along with recommendations for future work.

Potential sentence starters

If you’re not sure where to start, why not set a 10 minute timer and have a go at trying to finish a few of the following sentences. Not sure on what to put? Have a chat to your supervisor or lab mates and they may be able to suggest some ideas.

• This study is important to the field because…
• These findings advance the field by…
• Our results highlight the importance of…
• Our discoveries impact the field by…

Now you’ve had a go let’s have a look at some real life examples.

Statement of significance examples

A statement of significance / impact:

Impact Statement This review highlights the historical development of the concept of “ideal protein” that began in the 1950s and 1980s for poultry and swine diets, respectively, and the major conceptual deficiencies of the long-standing concept of “ideal protein” in animal nutrition based on recent advances in amino acid (AA) metabolism and functions. Nutritionists should move beyond the “ideal protein” concept to consider optimum ratios and amounts of all proteinogenic AAs in animal foods and, in the case of carnivores, also taurine. This will help formulate effective low-protein diets for livestock, poultry, and fish, while sustaining global animal production. Because they are not only species of agricultural importance, but also useful models to study the biology and diseases of humans as well as companion (e.g. dogs and cats), zoo, and extinct animals in the world, our work applies to a more general readership than the nutritionists and producers of farm animals. Wu G, Li P. The “ideal protein” concept is not ideal in animal nutrition.  Experimental Biology and Medicine . 2022;247(13):1191-1201. doi: 10.1177/15353702221082658

And the same type of section but this time called “Advances in knowledge”:

Advances in knowledge: According to the MY-RADs criteria, size measurements of focal lesions in MRI are now of relevance for response assessment in patients with monoclonal plasma cell disorders. Size changes of 1 or 2 mm are frequently observed due to uncertainty of the measurement only, while the actual focal lesion has not undergone any biological change. Size changes of at least 6 mm or more in  T 1  weighted or  T 2  weighted short tau inversion recovery sequences occur in only 5% or less of cases when the focal lesion has not undergone any biological change. Wennmann M, Grözinger M, Weru V, et al. Test-retest, inter- and intra-rater reproducibility of size measurements of focal bone marrow lesions in MRI in patients with multiple myeloma [published online ahead of print, 2023 Apr 12].  Br J Radiol . 2023;20220745. doi: 10.1259/bjr.20220745

Other examples of research significance

Moving beyond the formal statement of significance, here is how you can describe research significance more broadly within your paper.

Describing research impact in an Abstract of a paper:

Three-dimensional visualisation and quantification of the chondrocyte population within articular cartilage can be achieved across a field of view of several millimetres using laboratory-based micro-CT. The ability to map chondrocytes in 3D opens possibilities for research in fields from skeletal development through to medical device design and treatment of cartilage degeneration. Conclusions section of the abstract in my first paper .

In the Discussion section of a paper:

We report for the utility of a standard laboratory micro-CT scanner to visualise and quantify features of the chondrocyte population within intact articular cartilage in 3D. This study represents a complimentary addition to the growing body of evidence supporting the non-destructive imaging of the constituents of articular cartilage. This offers researchers the opportunity to image chondrocyte distributions in 3D without specialised synchrotron equipment, enabling investigations such as chondrocyte morphology across grades of cartilage damage, 3D strain mapping techniques such as digital volume correlation to evaluate mechanical properties  in situ , and models for 3D finite element analysis  in silico  simulations. This enables an objective quantification of chondrocyte distribution and morphology in three dimensions allowing greater insight for investigations into studies of cartilage development, degeneration and repair. One such application of our method, is as a means to provide a 3D pattern in the cartilage which, when combined with digital volume correlation, could determine 3D strain gradient measurements enabling potential treatment and repair of cartilage degeneration. Moreover, the method proposed here will allow evaluation of cartilage implanted with tissue engineered scaffolds designed to promote chondral repair, providing valuable insight into the induced regenerative process. The Discussion section of the paper is laced with references to research significance.

How is longer term research significance measured?

Looking beyond writing impact statements within papers, sometimes you’ll want to quantify the long term research significance of your work. For instance when applying for jobs.

The most obvious measure of a study’s long term research significance is the number of citations it receives from future publications. The thinking is that a study which receives more citations will have had more research impact, and therefore significance , than a study which received less citations. Citations can give a broad indication of how useful the work is to other researchers but citations aren’t really a good measure of significance.

Bear in mind that us researchers can be lazy folks and sometimes are simply looking to cite the first paper which backs up one of our claims. You can find studies which receive a lot of citations simply for packaging up the obvious in a form which can be easily found and referenced, for instance by having a catchy or optimised title.

Likewise, research activity varies wildly between fields. Therefore a certain study may have had a big impact on a particular field but receive a modest number of citations, simply because not many other researchers are working in the field.

Nevertheless, citations are a standard measure of significance and for better or worse it remains impressive for someone to be the first author of a publication receiving lots of citations.

Other measures for the research significance of a study include:

• Accolades: best paper awards at conferences, thesis awards, “most downloaded” titles for articles, press coverage.
• How much follow-on research the study creates. For instance, part of my PhD involved a novel material initially developed by another PhD student in the lab. That PhD student’s research had unlocked lots of potential new studies and now lots of people in the group were using the same material and developing it for different applications. The initial study may not receive a high number of citations yet long term it generated a lot of research activity.

That covers research significance, but you’ll often want to consider other types of significance for your study and we’ll cover those next.

Statistical Significance

What is the statistical significance of a study.

Often as part of a study you’ll carry out statistical tests and then state the statistical significance of your findings: think p-values eg <0.05. It is useful to describe the outcome of these tests within your report or paper, to give a measure of statistical significance.

Effectively you are trying to show whether the performance of your innovation is actually better than a control or baseline and not just chance. Statistical significance deserves a whole other post so I won’t go into a huge amount of depth here.

Things that make publication in  The BMJ  impossible or unlikely Internal validity/robustness of the study • It had insufficient statistical power, making interpretation difficult; • Lack of statistical power; The British Medical Journal’s guide for authors

Calculating statistical significance isn’t always necessary (or valid) for a study, such as if you have a very small number of samples, but it is a very common requirement for scientific articles.

Writing a journal article? Check the journal’s guide for authors to see what they expect. Generally if you have approximately five or more samples or replicates it makes sense to start thinking about statistical tests. Speak to your supervisor and lab mates for advice, and look at other published articles in your field.

How is statistical significance measured?

Statistical significance is quantified using p-values . Depending on your study design you’ll choose different statistical tests to compute the p-value.

A p-value of 0.05 is a common threshold value. The 0.05 means that there is a 1/20 chance that the difference in performance you’re reporting is just down to random chance.

• p-values above 0.05 mean that the result isn’t statistically significant enough to be trusted: it is too likely that the effect you’re showing is just luck.
• p-values less than or equal to 0.05 mean that the result is statistically significant. In other words: unlikely to just be chance, which is usually considered a good outcome.

Low p-values (eg p = 0.001) mean that it is highly unlikely to be random chance (1/1000 in the case of p = 0.001), therefore more statistically significant.

It is important to clarify that, although low p-values mean that your findings are statistically significant, it doesn’t automatically mean that the result is scientifically important. More on that in the next section on research significance.

How to describe the statistical significance of your study, with examples

In the first paper from my PhD I ran some statistical tests to see if different staining techniques (basically dyes) increased how well you could see cells in cow tissue using micro-CT scanning (a 3D imaging technique).

In your methods section you should mention the statistical tests you conducted and then in the results you will have statements such as:

Between mediums for the two scan protocols C/N [contrast to noise ratio] was greater for EtOH than the PBS in both scanning methods (both  p  < 0.0001) with mean differences of 1.243 (95% CI [confidence interval] 0.709 to 1.778) for absorption contrast and 6.231 (95% CI 5.772 to 6.690) for propagation contrast. … Two repeat propagation scans were taken of samples from the PTA-stained groups. No difference in mean C/N was found with either medium: PBS had a mean difference of 0.058 ( p  = 0.852, 95% CI -0.560 to 0.676), EtOH had a mean difference of 1.183 ( p  = 0.112, 95% CI 0.281 to 2.648). From the Results section of my first paper, available here . Square brackets added for this post to aid clarity.

From this text the reader can infer from the first paragraph that there was a statistically significant difference in using EtOH compared to PBS (really small p-value of <0.0001). However, from the second paragraph, the difference between two repeat scans was statistically insignificant for both PBS (p = 0.852) and EtOH (p = 0.112).

By conducting these statistical tests you have then earned your right to make bold statements, such as these from the discussion section:

Propagation phase-contrast increases the contrast of individual chondrocytes [cartilage cells] compared to using absorption contrast. From the Discussion section from the same paper.

Without statistical tests you have no evidence that your results are not just down to random chance.

Beyond describing the statistical significance of a study in the main body text of your work, you can also show it in your figures.

In figures such as bar charts you’ll often see asterisks to represent statistical significance, and “n.s.” to show differences between groups which are not statistically significant. Here is one such figure, with some subplots, from the same paper:

In this example an asterisk (*) between two bars represents p < 0.05. Two asterisks (**) represents p < 0.001 and three asterisks (***) represents p < 0.0001. This should always be stated in the caption of your figure since the values that each asterisk refers to can vary.

Now that we know if a study is showing statistically and research significance, let’s zoom out a little and consider the potential for commercial significance.

Commercial and Industrial Significance

What are commercial and industrial significance.

Moving beyond significance in relation to academia, your research may also have commercial or economic significance.

Simply put:

• Commercial significance: could the research be commercialised as a product or service? Perhaps the underlying technology described in your study could be licensed to a company or you could even start your own business using it.
• Industrial significance: more widely than just providing a product which could be sold, does your research provide insights which may affect a whole industry? Such as: revealing insights or issues with current practices, performance gains you don’t want to commercialise (e.g. solar power efficiency), providing suggested frameworks or improvements which could be employed industry-wide.

I’ve grouped these two together because there can certainly be overlap. For instance, perhaps your new technology could be commercialised whilst providing wider improvements for the whole industry.

Commercial and industrial significance are not relevant to most studies, so only write about it if you and your supervisor can think of reasonable routes to your work having an impact in these ways.

How are commercial and industrial significance measured?

Unlike statistical and research significances, the measures of commercial and industrial significance can be much more broad.

Here are some potential measures of significance:

Commercial significance:

• How much value does your technology bring to potential customers or users?
• How big is the potential market and how much revenue could the product potentially generate?
• Is the intellectual property protectable? i.e. patentable, or if not could the novelty be protected with trade secrets: if so publish your method with caution!
• If commercialised, could the product bring employment to a geographical area?

Industrial significance:

What impact could it have on the industry? For instance if you’re revealing an issue with something, such as unintended negative consequences of a drug , what does that mean for the industry and the public? This could be:

• Reduced overhead costs
• Better safety
• Faster production methods
• Improved scaleability

How to describe the commercial and industrial significance of a study, with examples

Commercial significance.

If your technology could be commercially viable, and you’ve got an interest in commercialising it yourself, it is likely that you and your university may not want to immediately publish the study in a journal.

You’ll probably want to consider routes to exploiting the technology and your university may have a “technology transfer” team to help researchers navigate the various options.

However, if instead of publishing a paper you’re submitting a thesis or dissertation then it can be useful to highlight the commercial significance of your work. In this instance you could include statements of commercial significance such as:

The measurement technology described in this study provides state of the art performance and could enable the development of low cost devices for aerospace applications. An example of commercial significance I invented for this post

Industrial significance

First, think about the industrial sectors who could benefit from the developments described in your study.

For example if you’re working to improve battery efficiency it is easy to think of how it could lead to performance gains for certain industries, like personal electronics or electric vehicles. In these instances you can describe the industrial significance relatively easily, based off your findings.

For example:

By utilising abundant materials in the described battery fabrication process we provide a framework for battery manufacturers to reduce dependence on rare earth components. Again, an invented example

For other technologies there may well be industrial applications but they are less immediately obvious and applicable. In these scenarios the best you can do is to simply reframe your research significance statement in terms of potential commercial applications in a broad way.

As a reminder: not all studies should address industrial significance, so don’t try to invent applications just for the sake of it!

Societal Significance

What is the societal significance of a study.

The most broad category of significance is the societal impact which could stem from it.

If you’re working in an applied field it may be quite easy to see a route for your research to impact society. For others, the route to societal significance may be less immediate or clear.

Studies can help with big issues facing society such as:

• Medical applications : vaccines, surgical implants, drugs, improving patient safety. For instance this medical device and drug combination I worked on which has a very direct route to societal significance.
• Political significance : Your research may provide insights which could contribute towards potential changes in policy or better understanding of issues facing society.
• Public health : for instance COVID-19 transmission and related decisions.
• Climate change : mitigation such as more efficient solar panels and lower cost battery solutions, and studying required adaptation efforts and technologies. Also, better understanding around related societal issues, for instance this study on the effects of temperature on hate speech.

How is societal significance measured?

Societal significance at a high level can be quantified by the size of its potential societal effect. Just like a lab risk assessment, you can think of it in terms of probability (or how many people it could help) and impact magnitude.

Societal impact = How many people it could help x the magnitude of the impact

Think about how widely applicable the findings are: for instance does it affect only certain people? Then think about the potential size of the impact: what kind of difference could it make to those people?

Between these two metrics you can get a pretty good overview of the potential societal significance of your research study.

How to describe the societal significance of a study, with examples

Quite often the broad societal significance of your study is what you’re setting the scene for in your Introduction. In addition to describing the existing literature, it is common to for the study’s motivation to touch on its wider impact for society.

For those of us working in healthcare research it is usually pretty easy to see a path towards societal significance.

Our CLOUT model has state-of-the-art performance in mortality prediction, surpassing other competitive NN models and a logistic regression model … Our results show that the risk factors identified by the CLOUT model agree with physicians’ assessment, suggesting that CLOUT could be used in real-world clinicalsettings. Our results strongly support that CLOUT may be a useful tool to generate clinical prediction models, especially among hospitalized and critically ill patient populations. Learning Latent Space Representations to Predict Patient Outcomes: Model Development and Validation

In other domains the societal significance may either take longer or be more indirect, meaning that it can be more difficult to describe the societal impact.

Even so, here are some examples I’ve found from studies in non-healthcare domains:

We examined food waste as an initial investigation and test of this methodology, and there is clear potential for the examination of not only other policy texts related to food waste (e.g., liability protection, tax incentives, etc.; Broad Leib et al., 2020) but related to sustainable fishing (Worm et al., 2006) and energy use (Hawken, 2017). These other areas are of obvious relevance to climate change… AI-Based Text Analysis for Evaluating Food Waste Policies

The continued development of state-of-the art NLP tools tailored to climate policy will allow climate researchers and policy makers to extract meaningful information from this growing body of text, to monitor trends over time and administrative units, and to identify potential policy improvements. BERT Classification of Paris Agreement Climate Action Plans

Top Tips For Identifying & Writing About the Significance of Your Study

• Writing a thesis? Describe the significance of your study in the Introduction and the Conclusion .
• Submitting a paper? Read the journal’s guidelines. If you’re writing a statement of significance for a journal, make sure you read any guidance they give for what they’re expecting.
• Take a step back from your research and consider your study’s main contributions.
• Read previously published studies in your field . Use this for inspiration and ideas on how to describe the significance of your own study
• Discuss the study with your supervisor and potential co-authors or collaborators and brainstorm potential types of significance for it.

Now you’ve finished reading up on the significance of a study you may also like my how-to guide for all aspects of writing your first research paper .

Writing an academic journal paper

I hope that you’ve learned something useful from this article about the significance of a study. If you have any more research-related questions let me know, I’m here to help.

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Significance of the Study

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The significance of the study underscores the research’s importance, illustrating its impact on existing knowledge and potential applications. It highlights how the findings address gaps, resolve problems, or contribute to advancements in a specific field. By emphasizing the study’s relevance, it demonstrates the broader implications for society, academia, or industry, justifying the research effort and investment.

What is the Significance of the Study?

The significance of the study illustrates the research’s importance, highlighting its impact on existing knowledge and potential applications. It addresses gaps, resolves problems, or contributes to advancements in a specific field. Emphasizing the study’s relevance, it demonstrates broader implications for society, academia, or industry, justifying the research effort and investment.

Significance of the Study Format

When writing the “Significance of the Study” section in a research paper , follow this format to ensure clarity and impact:

1. Introduction

• Contextual Background: Provide a brief background of the research topic.
• Research Problem: State the problem the study addresses.

2. Purpose of the Study

• Objective Statement: Clearly define the main objective of the study.
• Scope of the Study: Outline what the study covers.

3. Importance to the Field

• Contribution to Knowledge: Explain how the study will add to existing knowledge.
• Theoretical Significance: Discuss the study’s theoretical implications.

4. Practical Implications

• Real-world Application: Describe how the findings can be applied in practical setting .
• Beneficiaries: Identify who will benefit from the research (e.g., policymakers, practitioners, educators).

5. Advancement of Future Research

• Foundation for Future Studies: Indicate how the study can serve as a basis for further research.
• Research Gaps: Highlight any gaps the study aims to fill.

6. Societal Impact

• Broader Implications: Discuss the potential societal benefits or changes resulting from the study.
• Public Awareness: Explain how the study can raise awareness or understanding of the issue.

7. Conclusion

• Summary of Significance: Recap the main points that underline the importance of the study.
• Call to Action: Encourage specific actions or further studies based on the research findings.

Significance of the Study on Impact of Remote Work on Employee Productivity in the Tech Industry 1. Introduction The rapid shift to remote work due to the COVID-19 pandemic has fundamentally changed the dynamics of workplace productivity, especially within the tech industry. This study aims to examine how remote work influences employee productivity compared to traditional office settings. 2. Purpose of the Study The primary objective of this research is to evaluate the productivity levels of tech employees working remotely versus those working in office environments. The study analyzes various productivity metrics, such as task completion rates, quality of work, and employee satisfaction. 3. Importance to the Field This research contributes significantly to the existing body of knowledge by providing empirical data on the productivity impacts of remote work. It refines theoretical models of workplace productivity and offers new insights into remote work dynamics specific to the tech sector. Understanding these dynamics helps scholars and practitioners alike in shaping effective productivity strategies in the evolving work landscape. 4. Practical Implications The findings from this study have crucial practical implications for tech companies aiming to optimize their remote work policies. By understanding how remote work affects productivity, managers and HR departments can develop strategies to enhance employee performance and well-being in remote settings. These insights can also assist in designing training programs that equip employees with the skills needed for effective remote work. 5. Advancement of Future Research This study sets the stage for future research on long-term remote work trends and their impacts across various industries. It addresses existing gaps by providing a detailed analysis of how remote work influences productivity in the tech sector. Future researchers can build on this work to explore remote work dynamics in other fields and under different conditions. 6. Societal Impact The study highlights the broader societal implications of remote work, such as promoting work-life balance, reducing urban congestion, and lowering environmental pollution. By demonstrating the potential benefits of remote work, this research can influence public policy and corporate strategies towards more sustainable and flexible working conditions, ultimately contributing to societal well-being. 7. Conclusion Understanding the impact of remote work on productivity is essential for developing effective work policies and creating healthier work environments. This study provides valuable insights that can guide tech companies in optimizing their remote work strategies. Future research should explore the long-term effects of remote work across different sectors to provide a comprehensive understanding of its benefits and challenges.

Significance of the Study Examples

• Significance of the Study: Research Paper
• Significance of the Study: Qunatitive Research
• Significance of the Study: Qualitative Research

Research Paper

Qunatitive Research

Qualitative Research

More Significance of the Study Examples

• Educational Resources and Student Performance
• Business Innovation and Competitive Advantage
• Social Media Influencers and Brand Loyalty
• Mental Health Benefits of Physical Activ ity
• Sustainable Food Practices and Consumer Behavior
• Green Building and Energy Efficiency
• Technology in Healthcare
• Employee Engagement and Job Performance
• Business Strategies and Market Adaptation
• Mindfulness at Work

Purpose of Writing the Significance of a Study

When writing academic research or scholarly articles, one critical section is the significance of the study . This part addresses the importance and impact of the research, both theoretically and practically. Here are the main purposes of writing the significance of a study:

1. Establishing Relevance

The primary purpose is to explain why the study is relevant. It connects the research to existing literature, highlighting gaps or deficiencies that the current study aims to fill. This helps to justify the research problem and demonstrates the necessity of the study.

2. Highlighting Contributions

This section outlines the contributions the study will make to the field. It discusses how the findings can advance knowledge, theory, or practice. The significance emphasizes new insights, innovative approaches, or advancements that the study will provide.

3. Guiding Further Research

The significance of the study often includes suggestions for future research. By identifying limitations and unexplored areas, it encourages other researchers to pursue related questions. This helps to build a foundation for continuous inquiry and discovery.

4. Demonstrating Practical Applications

Beyond theoretical contributions, the significance of the study highlights practical applications. It shows how the research can solve real-world problems, improve practices, or influence policy-making. This connects academic research to practical outcomes that benefit society.

5. Engaging Stakeholders

Writing the significance of a study engages various stakeholders, including scholars, practitioners, policymakers, and funders. It communicates the value of the research to different audiences, making it easier to garner support, funding, or collaboration.

6. Enhancing Research Impact

A well-articulated significance section enhances the overall impact of the research. It underscores the importance and potential influence of the study, increasing its visibility and recognition in the academic community and beyond.

Benefits of Significance of the Study

Writing the significance of a study offers several benefits that enhance the research’s value and impact. Here are the key benefits:

1. Clarifies Research Value

The significance section clarifies the value of the research by explaining its importance and relevance. It helps readers understand why the study matters and what contributions it aims to make to the field.

2. Justifies the Research Problem

This section provides a rationale for the study by highlighting the research problem’s importance. It justifies the need for the study by identifying gaps in existing literature and explaining how the research will address these gaps.

3. Engages and Motivates Readers

A well-articulated significance section engages and motivates readers, including scholars, practitioners, and policymakers. It draws their interest by showcasing the study’s potential impact and benefits.

4. Secures Funding and Support

Explaining the significance of the study can help secure funding and support from stakeholders. Funding agencies and institutions are more likely to invest in research that demonstrates clear value and potential impact.

5. Guides Research Focus

The significance section helps guide the research focus by clearly defining the study’s contributions and goals. This clarity ensures that the research stays on track and aligns with its intended purpose.

6. Enhances Academic Credibility

Demonstrating the significance of a study enhances the researcher’s academic credibility. It shows a deep understanding of the field and the ability to identify and address important research questions.

7. Encourages Further Research

By identifying gaps and suggesting future research directions, the significance section encourages other researchers to build on the study’s findings. This fosters a continuous cycle of inquiry and discovery in the field.

8. Highlights Practical Applications

The significance section highlights practical applications of the research, showing how it can solve real-world problems. This makes the study more appealing to practitioners and policymakers who are interested in practical solutions.

9. Increases Research Impact

A clear and compelling significance section increases the overall impact of the research. It enhances the study’s visibility and recognition, leading to broader dissemination and application of the findings.

10. Supports Academic and Professional Goals

For researchers, writing a strong significance section supports academic and professional goals. It can contribute to career advancement, publication opportunities, and recognition within the academic community.

How to Write the Significance of the Study

Writing the significance of a study involves explaining the importance and impact of your research. This section should clearly articulate why your study matters, how it contributes to the field, and what practical applications it may have. Here’s a step-by-step guide to help you write an effective significance of the study:

Start with the Context

Begin by providing a brief overview of the research context. This sets the stage for understanding the importance of your study. Example : “In today’s digital age, digital literacy has become a critical skill for students. As technology continues to integrate into education, understanding its impact on academic performance is essential.”

Identify the Research Gap

Explain the gap in existing literature or the problem your study aims to address. Highlighting this gap justifies the need for your research. Example: “Despite the growing importance of digital literacy, there is limited empirical evidence on its direct impact on high school students’ academic performance. This study seeks to fill this gap by investigating this relationship.”

Explain the Theoretical Contributions

Discuss how your study will contribute to existing theories or knowledge in the field. This shows the academic value of your research. Example : “The findings of this study will contribute to educational theory by providing new insights into how digital literacy skills influence student learning outcomes. It will expand the current understanding of the role of technology in education.”

Highlight Practical Implications

Describe the practical applications of your research. Explain how the findings can be used in real-world settings. Example : “Practically, the results of this study can inform educators and policymakers about the importance of incorporating digital literacy programs into the curriculum. It will help design more effective teaching strategies that enhance students’ digital competencies.”

Mention the Beneficiaries

Identify who will benefit from your study. This could include scholars, practitioners, policymakers, or specific groups affected by the research problem. Example: “This research will benefit educators, school administrators, and policymakers by providing evidence-based recommendations for integrating digital literacy into educational practices. Additionally, students will benefit from improved learning outcomes and better preparedness for the digital world.”

Suggest Future Research

Point out areas for future research that stem from your study. This shows the ongoing relevance and potential for further inquiry. Example : “Future research could explore the long-term effects of digital literacy on career readiness and job performance. Additionally, studies could examine the impact of specific digital literacy interventions on diverse student populations.”

Use Clear and Concise Language

Ensure your writing is clear and concise. Avoid jargon and overly complex sentences to make your significance easily understandable.

What is the significance of a study?

The significance explains the importance, contributions, and impact of the research, highlighting why the study is necessary and how it benefits the field and society.

Why is the significance of a study important?

It justifies the research, engages readers, secures funding, guides the research focus, and highlights practical and theoretical contributions, enhancing the study’s impact and visibility.

How do you identify the significance of a study?

Identify gaps in existing literature, potential contributions to theory and practice, and practical applications that address real-world problems, demonstrating the study’s relevance and importance.

What should be included in the significance of a study?

Include the research context, identified gaps, theoretical contributions, practical applications, beneficiaries, and suggestions for future research to comprehensively explain the study’s importance.

How long should the significance of a study be?

Typically, the significance section should be concise, around 1-2 paragraphs, providing enough detail to clearly convey the study’s importance and contributions.

Can the significance of a study influence funding decisions?

Yes, a well-articulated significance section can attract funding by demonstrating the study’s potential impact and relevance to funding agencies and stakeholders.

How does the significance of a study benefit researchers?

It clarifies the research focus, enhances credibility, guides the research process, and supports academic and professional goals by highlighting the study’s contributions and importance.

Should the significance of a study mention future research?

Yes, mentioning future research directions shows the ongoing relevance of the study and encourages further inquiry, contributing to continuous advancement in the field.

How does the significance of a study relate to the research problem?

The significance justifies the research problem by explaining its importance, highlighting gaps in existing knowledge, and showing how the study addresses these issues.

Can practical applications be part of the significance of a study?

Yes, practical applications are crucial, showing how the research can solve real-world problems, influence practices, and benefit specific groups or society overall.

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• Instructive
• Professional

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How To Write a Significance Statement for Your Research

A significance statement is an essential part of a research paper. It explains the importance and relevance of the study to the academic community and the world at large. To write a compelling significance statement, identify the research problem, explain why it is significant, provide evidence of its importance, and highlight its potential impact on future research, policy, or practice. A well-crafted significance statement should effectively communicate the value of the research to readers and help them understand why it matters.

Updated on May 4, 2023

A significance statement is a clearly stated, non-technical paragraph that explains why your research matters. It’s central in making the public aware of and gaining support for your research.

Write it in jargon-free language that a reader from any field can understand. Well-crafted, easily readable significance statements can improve your chances for citation and impact and make it easier for readers outside your field to find and understand your work.

Read on for more details on what a significance statement is, how it can enhance the impact of your research, and, of course, how to write one.

What is a significance statement in research?

A significance statement answers the question: How will your research advance scientific knowledge and impact society at large (as well as specific populations)? 

You might also see it called a “Significance of the study” statement. Some professional organizations in the STEM sciences and social sciences now recommended that journals in their disciplines make such statements a standard feature of each published article. Funding agencies also consider “significance” a key criterion for their awards.

Read some examples of significance statements from the Proceedings of the National Academy of Sciences (PNAS) here .

Depending upon the specific journal or funding agency’s requirements, your statement may be around 100 words and answer these questions:

1. What’s the purpose of this research?

2. What are its key findings?

3. Why do they matter?

4. Who benefits from the research results?

Readers will want to know: “What is interesting or important about this research?” Keep asking yourself that question.

Where to place the significance statement in your manuscript

Most journals ask you to place the significance statement before or after the abstract, so check with each journal’s guide. 

This article is focused on the formal significance statement, even though you’ll naturally highlight your project’s significance elsewhere in your manuscript. (In the introduction, you’ll set out your research aims, and in the conclusion, you’ll explain the potential applications of your research and recommend areas for future research. You’re building an overall case for the value of your work.)

Developing the significance statement

The main steps in planning and developing your statement are to assess the gaps to which your study contributes, and then define your work’s implications and impact.

Identify what gaps your study fills and what it contributes

Your literature review was a big part of how you planned your study. To develop your research aims and objectives, you identified gaps or unanswered questions in the preceding research and designed your study to address them.

Go back to that lit review and look at those gaps again. Review your research proposal to refresh your memory. Ask:

• How have my research findings advanced knowledge or provided notable new insights?
• How has my research helped to prove (or disprove) a hypothesis or answer a research question?
• Why are those results important?

Consider your study’s potential impact at two levels: 

• What contribution does my research make to my field?
• How does it specifically contribute to knowledge; that is, who will benefit the most from it?

Define the implications and potential impact

As you make notes, keep the reasons in mind for why you are writing this statement. Whom will it impact, and why?

The first audience for your significance statement will be journal reviewers when you submit your article for publishing. Many journals require one for manuscript submissions. Study the author’s guide of your desired journal to see its criteria ( here’s an example ). Peer reviewers who can clearly understand the value of your research will be more likely to recommend publication. 

Second, when you apply for funding, your significance statement will help justify why your research deserves a grant from a funding agency . The U.S. National Institutes of Health (NIH), for example, wants to see that a project will “exert a sustained, powerful influence on the research field(s) involved.” Clear, simple language is always valuable because not all reviewers will be specialists in your field.

Third, this concise statement about your study’s importance can affect how potential readers engage with your work. Science journalists and interested readers can promote and spread your work, enhancing your reputation and influence. Help them understand your work.

You’re now ready to express the importance of your research clearly and concisely. Time to start writing.

How to write a significance statement: Key elements 

When drafting your statement, focus on both the content and writing style.

• In terms of content, emphasize the importance, timeliness, and relevance of your research results. 
• Write the statement in plain, clear language rather than scientific or technical jargon. Your audience will include not just your fellow scientists but also non-specialists like journalists, funding reviewers, and members of the public. 

Follow the process we outline below to build a solid, well-crafted, and informative statement. 

Get started

Some suggested opening lines to help you get started might be:

• The implications of this study are… 
• Building upon previous contributions, our study moves the field forward because…
• Our study furthers previous understanding about…

Alternatively, you may start with a statement about the phenomenon you’re studying, leading to the problem statement.

Include these components

Next, draft some sentences that include the following elements. A good example, which we’ll use here, is a significance statement by Rogers et al. (2022) published in the Journal of Climate .

1. Briefly situate your research study in its larger context . Start by introducing the topic, leading to a problem statement. Here’s an example:

‘Heatwaves pose a major threat to human health, ecosystems, and human systems.”

2. State the research problem.

“Simultaneous heatwaves affecting multiple regions can exacerbate such threats. For example, multiple food-producing regions simultaneously undergoing heat-related crop damage could drive global food shortages.”

3. Tell what your study does to address it.

“We assess recent changes in the occurrence of simultaneous large heatwaves.”

4. Provide brief but powerful evidence to support the claims your statement is making , Use quantifiable terms rather than vague ones (e.g., instead of “This phenomenon is happening now more than ever,” see below how Rogers et al. (2022) explained it). This evidence intensifies and illustrates the problem more vividly:

“Such simultaneous heatwaves are 7 times more likely now than 40 years ago. They are also hotter and affect a larger area. Their increasing occurrence is mainly driven by warming baseline temperatures due to global heating, but changes in weather patterns contribute to disproportionate increases over parts of Europe, the eastern United States, and Asia.

5. Relate your study’s impact to the broader context , starting with its general significance to society—then, when possible, move to the particular as you name specific applications of your research findings. (Our example lacks this second level of application.) 

“Better understanding the drivers of weather pattern changes is therefore important for understanding future concurrent heatwave characteristics and their impacts.”

Refine your English

Don’t understate or overstate your findings – just make clear what your study contributes. When you have all the elements in place, review your draft to simplify and polish your language. Even better, get an expert AJE edit . Be sure to use “plain” language rather than academic jargon.

• Avoid acronyms, scientific jargon, and technical terms 
• Use active verbs in your sentence structure rather than passive voice (e.g., instead of “It was found that...”, use “We found...”)
• Make sentence structures short, easy to understand – readable
• Try to address only one idea in each sentence and keep sentences within 25 words (15 words is even better)
• Eliminate nonessential words and phrases (“fluff” and wordiness)

Enhance your significance statement’s impact

Always take time to review your draft multiple times. Make sure that you:

• Keep your language focused
• Provide evidence to support your claims
• Relate the significance to the broader research context in your field

After revising your significance statement, request feedback from a reading mentor about how to make it even clearer. If you’re not a native English speaker, seek help from a native-English-speaking colleague or use an editing service like AJE to make sure your work is at a native level.

Understanding the significance of your study

Your readers may have much less interest than you do in the specific details of your research methods and measures. Many readers will scan your article to learn how your findings might apply to them and their own research. 

Different types of significance

Your findings may have different types of significance, relevant to different populations or fields of study for different reasons. You can emphasize your work’s statistical, clinical, or practical significance. Editors or reviewers in the social sciences might also evaluate your work’s social or political significance.

Statistical significance means that the results are unlikely to have occurred randomly. Instead, it implies a true cause-and-effect relationship.

Clinical significance means that your findings are applicable for treating patients and improving quality of life.

Practical significance is when your research outcomes are meaningful to society at large, in the “real world.” Practical significance is usually measured by the study’s  effect size . Similarly, evaluators may attribute social or political significance to research that addresses “real and immediate” social problems.

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What is the Significance of the Study?

• By DiscoverPhDs
• August 25, 2020

• what the significance of the study means,
• why it’s important to include in your research work,
• where you would include it in your paper, thesis or dissertation,
• how you write one
• and finally an example of a well written section about the significance of the study.

What does Significance of the Study mean?

The significance of the study is a written statement that explains why your research was needed. It’s a justification of the importance of your work and impact it has on your research field, it’s contribution to new knowledge and how others will benefit from it.

Why is the Significance of the Study important?

The significance of the study, also known as the rationale of the study, is important to convey to the reader why the research work was important. This may be an academic reviewer assessing your manuscript under peer-review, an examiner reading your PhD thesis, a funder reading your grant application or another research group reading your published journal paper. Your academic writing should make clear to the reader what the significance of the research that you performed was, the contribution you made and the benefits of it.

How do you write the Significance of the Study?

When writing this section, first think about where the gaps in knowledge are in your research field. What are the areas that are poorly understood with little or no previously published literature? Or what topics have others previously published on that still require further work. This is often referred to as the problem statement.

The introduction section within the significance of the study should include you writing the problem statement and explaining to the reader where the gap in literature is.

Then think about the significance of your research and thesis study from two perspectives: (1) what is the general contribution of your research on your field and (2) what specific contribution have you made to the knowledge and who does this benefit the most.

For example, the gap in knowledge may be that the benefits of dumbbell exercises for patients recovering from a broken arm are not fully understood. You may have performed a study investigating the impact of dumbbell training in patients with fractures versus those that did not perform dumbbell exercises and shown there to be a benefit in their use. The broad significance of the study would be the improvement in the understanding of effective physiotherapy methods. Your specific contribution has been to show a significant improvement in the rate of recovery in patients with broken arms when performing certain dumbbell exercise routines.

This statement should be no more than 500 words in length when written for a thesis. Within a research paper, the statement should be shorter and around 200 words at most.

Significance of the Study: An example

Building on the above hypothetical academic study, the following is an example of a full statement of the significance of the study for you to consider when writing your own. Keep in mind though that there’s no single way of writing the perfect significance statement and it may well depend on the subject area and the study content.

Here’s another example to help demonstrate how a significance of the study can also be applied to non-technical fields:

The significance of this research lies in its potential to inform clinical practices and patient counseling. By understanding the psychological outcomes associated with non-surgical facial aesthetics, practitioners can better guide their patients in making informed decisions about their treatment plans. Additionally, this study contributes to the body of academic knowledge by providing empirical evidence on the effects of these cosmetic procedures, which have been largely anecdotal up to this point.

The statement of the significance of the study is used by students and researchers in academic writing to convey the importance of the research performed; this section is written at the end of the introduction and should describe the specific contribution made and who it benefits.

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How to Write Significance of the Study in a Project Research Paper

When you write your thesis or research paper, there is a section of your introduction that is allotted to the significance of the study. The purpose of this section is to state why your study was needed and the contribution of your research to your field.

In this guide, you will learn the meaning of the significance of the study in your research paper and how to write one.

What is the Significance of the Study?

The significance of the study is basically a written statement that explains why your research was important. It justifies why your research was needed, the impact of your research in your field, its contribution, and how others (audience) would benefit from it.

Also referred to as the rationale of the study, the significance of the study is important to communicate why your research is important to your reader. It is important to make clear the significance of your study for easy comprehension by the readers.

Tips for writing the significance of the study

Reflect on the Problem Statement When writing this section of your paper, first reflect on what contribution your research is making to your field, the gaps in knowledge in your research field, and why your work should be published.

Your problem statement should be reflected in the introduction of the significance of the study. Your research problem statement can guide you to identify specific contributions your research is making to your field of study.

Write from a general contribution to a specific contribution Write your significance of the study in an inverted pyramid format. Start with your research contribution to society as a whole, and then proceed to narrow it down to a specific individual or group of people.

When writing your statement of study, the length should not be more than 500 words for a thesis and around 200 words for a research paper.

However, note that writing the significance of study depends on your subject area and your content as there is no single way of writing a perfect significance of study.

An Example of Significance of Study

This study's findings will further reveal how management-employee bilateral relationships can be strengthened while improving workplace productivity. The findings would be of major importance in assessing how collective bargaining can be a major tool in improving workplace performance in a developing economy like Nigeria. Collective bargaining would help both management and employees bargain on terms and conditions of service and resolve their grievances without leading to strikes, lock-outs, and other forms of industrial actions. The best approach in negotiating on the bargaining table is to provide employees with the importance of collective bargaining as the best method of settling the industrial conflict, which will improve their productivity and lead to higher organizational performance.

The significance of the study is used in academic writing by students and researchers to communicate the importance of a research problem. This section describes specific contributions made to your field of study and who benefits from it. Also, the extent to which the study matters and its potential benefits to people, researchers, departments and other fields are discussed here. This statement is written at the end of your introduction and should be well attended to.

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How to Discuss the Significance of Your Research

6-minute read

• 10th April 2023

Introduction

Research papers can be a real headache for college students . As a student, your research needs to be credible enough to support your thesis statement. You must also ensure you’ve discussed the literature review, findings, and results.

However, it’s also important to discuss the significance of your research . Your potential audience will care deeply about this. It will also help you conduct your research. By knowing the impact of your research, you’ll understand what important questions to answer.

If you’d like to know more about the impact of your research, read on! We’ll talk about why it’s important and how to discuss it in your paper.

What Is the Significance of Research?

This is the potential impact of your research on the field of study. It includes contributions from new knowledge from the research and those who would benefit from it. You should present this before conducting research, so you need to be aware of current issues associated with the thesis before discussing the significance of the research.

Why Does the Significance of Research Matter?

Potential readers need to know why your research is worth pursuing. Discussing the significance of research answers the following questions:

●  Why should people read your research paper ?

●  How will your research contribute to the current knowledge related to your topic?

●  What potential impact will it have on the community and professionals in the field?

Not including the significance of research in your paper would be like a knight trying to fight a dragon without weapons.

Where Do I Discuss the Significance of Research in My Paper?

As previously mentioned, the significance of research comes before you conduct it. Therefore, you should discuss the significance of your research in the Introduction section. Your reader should know the problem statement and hypothesis beforehand.

Steps to Discussing the Significance of Your Research

Discussing the significance of research might seem like a loaded question, so we’ve outlined some steps to help you tackle it.

Step 1: The Research Problem

The problem statement can reveal clues about the outcome of your research. Your research should provide answers to the problem, which is beneficial to all those concerned. For example, imagine the problem statement is, “To what extent do elementary and high school teachers believe cyberbullying affects student performance?”

Learning teachers’ opinions on the effects of cyberbullying on student performance could result in the following:

●  Increased public awareness of cyberbullying in elementary and high schools

●  Teachers’ perceptions of cyberbullying negatively affecting student performance

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●  Whether cyberbullying is more prevalent in elementary or high schools

The research problem will steer your research in the right direction, so it’s best to start with the problem statement.

Step 2: Existing Literature in the Field

Think about current information on your topic, and then find out what information is missing. Are there any areas that haven’t been explored? Your research should add new information to the literature, so be sure to state this in your discussion. You’ll need to know the current literature on your topic anyway, as this is part of your literature review section .

Step 3: Your Research’s Impact on Society

Inform your readers about the impact on society your research could have on it. For example, in the study about teachers’ opinions on cyberbullying, you could mention that your research will educate the community about teachers’ perceptions of cyberbullying as it affects student performance. As a result, the community will know how many teachers believe cyberbullying affects student performance.

You can also mention specific individuals and institutions that would benefit from your study. In the example of cyberbullying, you might indicate that school principals and superintendents would benefit from your research.

Step 4: Future Studies in the Field

Next, discuss how the significance of your research will benefit future studies, which is especially helpful for future researchers in your field. In the example of cyberbullying affecting student performance, your research could provide further opportunities to assess teacher perceptions of cyberbullying and its effects on students from larger populations. This prepares future researchers for data collection and analysis.

Discussing the significance of your research may sound daunting when you haven’t conducted it yet. However, an audience might not read your paper if they don’t know the significance of the research. By focusing on the problem statement and the research benefits to society and future studies, you can convince your audience of the value of your research.

Remember that everything you write doesn’t have to be set in stone. You can go back and tweak the significance of your research after conducting it. At first, you might only include general contributions of your study, but as you research, your contributions will become more specific.

You should have a solid understanding of your topic in general, its associated problems, and the literature review before tackling the significance of your research. However, you’re not trying to prove your thesis statement at this point. The significance of research just convinces the audience that your study is worth reading.

Finally, we always recommend seeking help from your research advisor whenever you’re struggling with ideas. For a more visual idea of how to discuss the significance of your research, we suggest checking out this video .

1. Do I need to do my research before discussing its significance?

No, you’re discussing the significance of your research before you conduct it. However, you should be knowledgeable about your topic and the related literature.

2. Is the significance of research the same as its implications?

No, the research implications are potential questions from your study that justify further exploration, which comes after conducting the research.

 3. Discussing the significance of research seems overwhelming. Where should I start?

We recommend the problem statement as a starting point, which reveals clues to the potential outcome of your research.

4. How can I get feedback on my discussion of the significance of my research?

Our proofreading experts can help. They’ll check your writing for grammar, punctuation errors, spelling, and concision. Submit a 500-word document for free today!

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Home » Feature » Thesis » Significance of the Study Samples | Writing Tips

Significance of the Study Samples | Writing Tips

When you write a thesis , there is a section there that is allocated for the significance of the study. This article will provide different  significance of the study examples and will discuss tips on how to write this part.

Tips in Writing the Significance of the Study

Here are the tips that may be helpful when writing the significance of the study. These tips will tell you the basic components expected to be seen in the significance of the study content.

1. Refer to the Problem Statement

In writing the significance of the study, always refer to the statement of the problem. This way, you can clearly define the contribution of your study. To simplify, your research should answer this question, “What are the benefits or advantages of the study based on the statement of the problem?”

Start by explaining the problem that your study aimed to solve. For example, if you conducted a research study on obesity rates among elementary school students, you would start by explaining that obesity is a major health concern in the Philippines and discuss why it is important to find ways to address this issue.

2. Write it from General to Particular

Determine the specific contribution of your thesis study to society as well as to the individual. Write it deductively, starting from general to specific. Start your significance of the study broadly then narrow it out to a specific group or person. This is done by looking into the general contribution of your study, such as its importance to society as a whole, then moving towards its contribution to individuals like yourself as a researcher.

Discuss how your study fills a gap in the literature. If you conducted an experiment on the effects of a certain type of food on children, for example, you might start by explaining that no research has been done on this topic before. This section would also include a discussion about why your study is important.

Your problem statement might help you determine the unique contribution of your research. This can be accomplished by ensuring that the aim of the problem and the study’s objectives are identical. For instance, if your research question is “Is there a significant relationship between the use of Facebook Messenger and the performance of students in English spelling? “, you could write as one of the contributions of your study: “The study will identify common errors in spelling and grammar by Messenger users and recommend its appropriate use in a way that can improve performance in spelling.”

You may also read: How to Make a Conceptual Framework

Significance of the Study Samples

Here are some examples to help you draft your own introduction:

Title: Number of Clinical Internship Hours: A Determinant of Student’s Effectiveness and Skill  Acquisition in the Hospital Area for Velez College Students

Significance of the study.

The results of the study will be of great benefit to the following:

College of Nursing Dean . Data given will provide the dean with information on how the number of duty hours in a week affects the student’s academic and RLE performance. The results will enable the dean to improve the scheduling of RLE and different academic subjects. Data gathered will help the dean initiate collaboration among faculty and chairpersons to help plan the advancement of nursing education in relation to the new curriculum.

Clinical Instructors . The results of the study will help the clinical instructors evaluate the quality of care rendered by the nursing students, academic performance, attitude and skills acquired in relation to the number of hours given in a week. Results would also develop the clinical instructor’s teaching-learning and evaluating strategies in enhancing knowledge, skills and attitude to the students in the time frame given.

Students . This study will provide information regarding which time arrangement is effective: 8-hr of clinical internship from the 5-hr clinical internship with additional academic classes. This study will evaluate the academic performance, the student nurse’s attitude and approach, the skills learned in the clinical area, and the quality of care rendered in the given time frame. Data gathered will also help the students improve both academic and clinical performance.

Velez College . This study will improve the school in the development of nursing education. This study will foster new ways of enhancing knowledge, skills, and attitude, thus preparing globally-competitive nurses in the future. This study will also help in the advancement of school management, clinical leadership, and the teaching-evaluation approach.

Title: The Effectiveness of Isuzu’s Blue Power Technology in Fuel Efficiency of Diesel Engines

The generalization of this study would be a great contribution to the vast knowledge in relation to the brand awareness of Isuzu’s Blue Power Euro 4 Technology. Furthermore, the results of this investigation could be highly significant and beneficial for the following:

Current Customers

They refer to consumers that have already bought products from Isuzu. They are considered to be the main beneficiaries of the business. The findings of this study would provide them with adequate information about the product, most especially for those clients that have already bought units with the Blue Power Euro 4 Technology but have no idea of its benefits and advantages.

Potential Customer

They are the consumers that have not yet purchased this brand. This study aims to give them insights and overviews of the product and would help them choose the right variant to purchase.

They are the main beneficiaries of this study, which may help them to improve their marketing strategies. It would provide substantial data to the business that they could make use of in boosting their sales. Moreover, developing brand awareness will cater to more demands and loyalty in the future.

For they also play a vital role in the business and as consumers. This research would give them the idea that such private vehicles exist, which helps them to conserve energy rather than exploit it. Hence, giving back to the community and making it a better place to live.

Proponents of the Study

This refers to the students conducting the study. They will find self-fulfillment and gain knowledge and skills in this study. This study will help and inspire more researchers to be more innovative and creative in their future endeavors.

Future Researchers

This study will serve as a reference for researchers on the subject of research in the field of marketing. This will serve as a guide to further developing the research with the connection to the variables used.

The significance of a study is a key component of a strong scientific paper. By following these tips, you can create a clear and concise explanation of the importance of your work. I hope that these tips and samples will help you create a perfect Significance of the Study for your thesis. Apply these tips to prevent your mind from wandering aimlessly as you draft the significance of the study. It will allow you to focus on the next section of your thesis, helping you finish it on time. Good luck!

good and interesting

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Very useful. Thanks

Thank you for a very informative article

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How to Write Significance of the Study

• Posted in Conducting Research / Education Research / Science Education Research
• Updated July 1, 2023
• 3 mins read

The significance of a study is a crucial aspect that conveys the importance and relevance of the research conducted. It highlights the contribution and impact of the study in advancing knowledge, addressing gaps in the field, and informing practice or policy. Here are the steps, along with examples and illustrations, in writing the significance of a study:

• Identify the Research Gap

Begin by identifying the specific gap or limitation in the existing literature or knowledge that the study aims to address. This could be a gap in understanding, unresolved controversies, or unexplored areas. For example:

Illustration

In the field of science education, there might be limited research exploring the impact of hands-on inquiry-based learning approaches on students’ conceptual understanding of complex scientific concepts.

• Highlight the Relevance

Clearly articulate why the identified research gap is significant and relevant to the field of study, educational practice, or society at large. Emphasize the potential benefits or implications of filling the gap. For example:

Addressing the research gap in understanding the impact of hands-on inquiry-based learning approaches can contribute to the development of effective instructional strategies that promote students’ conceptual understanding, scientific thinking skills, and engagement in science education. This, in turn, can enhance students’ science achievement and prepare them for future scientific careers.

• Discuss the Potential Contributions

Explain the potential contributions and novelty of the study. This could include methodological advancements, theoretical insights, practical implications, or policy recommendations. For example:

This study aims to contribute to the field of science education by providing empirical evidence on the effectiveness of hands-on inquiry-based learning approaches in fostering students’ conceptual understanding. The findings can inform curriculum development, teacher professional development programs, and instructional practices that promote active engagement and deeper learning in science education.

4.Consider the Broader Impact

Reflect on the broader impact of the study beyond the immediate research context. Discuss how the study aligns with broader educational goals, societal needs, or interdisciplinary connections. For example:

The findings of this study have the potential to inform educational policies and practices aimed at promoting STEM (science, technology, engineering, and mathematics) education, fostering scientific literacy, and addressing the growing demand for a scientifically literate workforce in a technology-driven society.

• Summarize the Significance

Summarize the significance of the study in a concise and compelling manner, emphasizing the gap addressed, the relevance to the field, and the potential contributions and impact. For example:

This study fills a critical research gap by investigating the impact of hands-on inquiry-based learning approaches on students’ conceptual understanding in science education. The findings have the potential to inform instructional practices, curriculum development, and educational policies, contributing to the advancement of science education and preparing students for future scientific endeavors.

Writing the significance of the study involves effectively conveying the importance and value of the research to various stakeholders, including researchers, educators, policymakers, and the broader community. By following these steps and providing clear examples and illustrations, researchers can effectively communicate the significance of their study and generate interest in their research.

Creswell, J. W. (2014). Research Design: Qualitative, Quantitative, and Mixed Methods Approaches. SAGE Publications.

Gall, M. D., Gall, J. P., & Borg, W. R. (2006). Educational Research: An Introduction (8th ed.). Pearson.

Leedy, P. D., & Ormrod, J. E. (2014). Practical Research: Planning and Design (11th ed.). Pearson.

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Writing the Significance of a Study

By charlesworth author services.

• Charlesworth Author Services
• 20 July, 2022

The significance of a study is its importance . It refers to the contribution(s) to and impact of the study on a research field. The significance also signals who benefits from the research findings and how.

Purpose of writing the significance of a study

A study’s significance should spark the interest of the reader. Researchers will be able to appreciate your work better when they understand the relevance and its (potential) impact. Peer reviewers also assess the significance of the work, which will influence the decision made (acceptance/rejection) on the manuscript. 

Sections in which the significance of the study is written

Introduction.

In the Introduction of your paper, the significance appears where you talk about the potential importance and impact of the study. It should flow naturally from the problem , aims and objectives, and rationale .

The significance is described in more detail in the concluding paragraph(s) of the Discussion or the dedicated Conclusions section. Here, you put the findings into perspective and outline the contributions of the findings in terms of implications and applications.

The significance may or may not appear in the abstract . When it does, it is written in the concluding lines of the abstract.

Significance vs. other introductory elements of your paper

In the Introduction…

• The problem statement outlines the concern that needs to be addressed.
• The research aim describes the purpose of the study.
• The objectives indicate how that aim will be achieved.
• The rationale explains why you are performing the study.
• The significance tells the reader how the findings affect the topic/broad field. In other words, the significance is about how much the findings matter.

How to write the significance of the study

A good significance statement may be written in different ways. The approach to writing it also depends on the study area. In the arts and humanities , the significance statement might be longer and more descriptive. In applied sciences , it might be more direct.

a. Suggested sequence for writing the significance statement

• Think of the gaps your study is setting out to address.
• Look at your research from general and specific angles in terms of its (potential) contribution .
• Once you have these points ready, start writing them, connecting them to your study as a whole.

b. Some ways to begin your statement(s) of significance

Here are some opening lines to build on:

• The particular significance of this study lies in the… 
• We argue that this study moves the field forward because…
• This study makes some important contributions to…
• Our findings deepen the current understanding about…

c. Don’ts of writing a significance statement

• Don’t make it too long .
• Don’t repeat any information that has been presented in other sections.
• Don’t overstate or exaggerat e the importance; it should match your actual findings.

Example of significance of a study

Note the significance statements highlighted in the following fictional study.

Significance in the Introduction

The effects of Miyawaki forests on local biodiversity in urban housing complexes remain poorly understood. No formal studies on negative impacts on insect activity, populations or diversity have been undertaken thus far. In this study, we compared the effects that Miyawaki forests in urban dwellings have on local pollinator activity. The findings of this study will help improve the design of this afforestation technique in a way that balances local fauna, particularly pollinators, which are highly sensitive to microclimatic changes.

Significance in the Conclusion

[…] The findings provide valuable insights for guiding and informing Miyawaki afforestation in urban dwellings. We demonstrate that urban planning and landscaping policies need to consider potential declines.

A study’s significance usually appears at the end of the Introduction and in the Conclusion to describe the importance of the research findings. A strong and clear significance statement will pique the interest of readers, as well as that of relevant stakeholders.

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Home » Background of The Study – Examples and Writing Guide

Background of The Study – Examples and Writing Guide

Table of Contents

Background of The Study

Definition:

Background of the study refers to the context, circumstances, and history that led to the research problem or topic being studied. It provides the reader with a comprehensive understanding of the subject matter and the significance of the study.

The background of the study usually includes a discussion of the relevant literature, the gap in knowledge or understanding, and the research questions or hypotheses to be addressed. It also highlights the importance of the research topic and its potential contributions to the field. A well-written background of the study sets the stage for the research and helps the reader to appreciate the need for the study and its potential significance.

How to Write Background of The Study

Here are some steps to help you write the background of the study:

Identify the Research Problem

Start by identifying the research problem you are trying to address. This problem should be significant and relevant to your field of study.

Provide Context

Once you have identified the research problem, provide some context. This could include the historical, social, or political context of the problem.

Review Literature

Conduct a thorough review of the existing literature on the topic. This will help you understand what has been studied and what gaps exist in the current research.

Identify Research Gap

Based on your literature review, identify the gap in knowledge or understanding that your research aims to address. This gap will be the focus of your research question or hypothesis.

State Objectives

Clearly state the objectives of your research . These should be specific, measurable, achievable, relevant, and time-bound (SMART).

Discuss Significance

Explain the significance of your research. This could include its potential impact on theory , practice, policy, or society.

Finally, summarize the key points of the background of the study. This will help the reader understand the research problem, its context, and its significance.

How to Write Background of The Study in Proposal

The background of the study is an essential part of any proposal as it sets the stage for the research project and provides the context and justification for why the research is needed. Here are the steps to write a compelling background of the study in your proposal:

• Identify the problem: Clearly state the research problem or gap in the current knowledge that you intend to address through your research.
• Provide context: Provide a brief overview of the research area and highlight its significance in the field.
• Review literature: Summarize the relevant literature related to the research problem and provide a critical evaluation of the current state of knowledge.
• Identify gaps : Identify the gaps or limitations in the existing literature and explain how your research will contribute to filling these gaps.
• Justify the study : Explain why your research is important and what practical or theoretical contributions it can make to the field.
• Highlight objectives: Clearly state the objectives of the study and how they relate to the research problem.
• Discuss methodology: Provide an overview of the methodology you will use to collect and analyze data, and explain why it is appropriate for the research problem.
• Conclude : Summarize the key points of the background of the study and explain how they support your research proposal.

How to Write Background of The Study In Thesis

The background of the study is a critical component of a thesis as it provides context for the research problem, rationale for conducting the study, and the significance of the research. Here are some steps to help you write a strong background of the study:

• Identify the research problem : Start by identifying the research problem that your thesis is addressing. What is the issue that you are trying to solve or explore? Be specific and concise in your problem statement.
• Review the literature: Conduct a thorough review of the relevant literature on the topic. This should include scholarly articles, books, and other sources that are directly related to your research question.
• I dentify gaps in the literature: After reviewing the literature, identify any gaps in the existing research. What questions remain unanswered? What areas have not been explored? This will help you to establish the need for your research.
• Establish the significance of the research: Clearly state the significance of your research. Why is it important to address this research problem? What are the potential implications of your research? How will it contribute to the field?
• Provide an overview of the research design: Provide an overview of the research design and methodology that you will be using in your study. This should include a brief explanation of the research approach, data collection methods, and data analysis techniques.
• State the research objectives and research questions: Clearly state the research objectives and research questions that your study aims to answer. These should be specific, measurable, achievable, relevant, and time-bound.
• Summarize the chapter: Summarize the chapter by highlighting the key points and linking them back to the research problem, significance of the study, and research questions.

How to Write Background of The Study in Research Paper

Here are the steps to write the background of the study in a research paper:

• Identify the research problem: Start by identifying the research problem that your study aims to address. This can be a particular issue, a gap in the literature, or a need for further investigation.
• Conduct a literature review: Conduct a thorough literature review to gather information on the topic, identify existing studies, and understand the current state of research. This will help you identify the gap in the literature that your study aims to fill.
• Explain the significance of the study: Explain why your study is important and why it is necessary. This can include the potential impact on the field, the importance to society, or the need to address a particular issue.
• Provide context: Provide context for the research problem by discussing the broader social, economic, or political context that the study is situated in. This can help the reader understand the relevance of the study and its potential implications.
• State the research questions and objectives: State the research questions and objectives that your study aims to address. This will help the reader understand the scope of the study and its purpose.
• Summarize the methodology : Briefly summarize the methodology you used to conduct the study, including the data collection and analysis methods. This can help the reader understand how the study was conducted and its reliability.

Examples of Background of The Study

Here are some examples of the background of the study:

Problem : The prevalence of obesity among children in the United States has reached alarming levels, with nearly one in five children classified as obese.

Significance : Obesity in childhood is associated with numerous negative health outcomes, including increased risk of type 2 diabetes, cardiovascular disease, and certain cancers.

Gap in knowledge : Despite efforts to address the obesity epidemic, rates continue to rise. There is a need for effective interventions that target the unique needs of children and their families.

Problem : The use of antibiotics in agriculture has contributed to the development of antibiotic-resistant bacteria, which poses a significant threat to human health.

Significance : Antibiotic-resistant infections are responsible for thousands of deaths each year and are a major public health concern.

Gap in knowledge: While there is a growing body of research on the use of antibiotics in agriculture, there is still much to be learned about the mechanisms of resistance and the most effective strategies for reducing antibiotic use.

Edxample 3:

Problem : Many low-income communities lack access to healthy food options, leading to high rates of food insecurity and diet-related diseases.

Significance : Poor nutrition is a major contributor to chronic diseases such as obesity, type 2 diabetes, and cardiovascular disease.

Gap in knowledge : While there have been efforts to address food insecurity, there is a need for more research on the barriers to accessing healthy food in low-income communities and effective strategies for increasing access.

Examples of Background of The Study In Research

Here are some real-life examples of how the background of the study can be written in different fields of study:

Example 1 : “There has been a significant increase in the incidence of diabetes in recent years. This has led to an increased demand for effective diabetes management strategies. The purpose of this study is to evaluate the effectiveness of a new diabetes management program in improving patient outcomes.”

Example 2 : “The use of social media has become increasingly prevalent in modern society. Despite its popularity, little is known about the effects of social media use on mental health. This study aims to investigate the relationship between social media use and mental health in young adults.”

Example 3: “Despite significant advancements in cancer treatment, the survival rate for patients with pancreatic cancer remains low. The purpose of this study is to identify potential biomarkers that can be used to improve early detection and treatment of pancreatic cancer.”

Examples of Background of The Study in Proposal

Here are some real-time examples of the background of the study in a proposal:

Example 1 : The prevalence of mental health issues among university students has been increasing over the past decade. This study aims to investigate the causes and impacts of mental health issues on academic performance and wellbeing.

Example 2 : Climate change is a global issue that has significant implications for agriculture in developing countries. This study aims to examine the adaptive capacity of smallholder farmers to climate change and identify effective strategies to enhance their resilience.

Example 3 : The use of social media in political campaigns has become increasingly common in recent years. This study aims to analyze the effectiveness of social media campaigns in mobilizing young voters and influencing their voting behavior.

Example 4 : Employee turnover is a major challenge for organizations, especially in the service sector. This study aims to identify the key factors that influence employee turnover in the hospitality industry and explore effective strategies for reducing turnover rates.

Examples of Background of The Study in Thesis

Here are some real-time examples of the background of the study in the thesis:

Example 1 : “Women’s participation in the workforce has increased significantly over the past few decades. However, women continue to be underrepresented in leadership positions, particularly in male-dominated industries such as technology. This study aims to examine the factors that contribute to the underrepresentation of women in leadership roles in the technology industry, with a focus on organizational culture and gender bias.”

Example 2 : “Mental health is a critical component of overall health and well-being. Despite increased awareness of the importance of mental health, there are still significant gaps in access to mental health services, particularly in low-income and rural communities. This study aims to evaluate the effectiveness of a community-based mental health intervention in improving mental health outcomes in underserved populations.”

Example 3: “The use of technology in education has become increasingly widespread, with many schools adopting online learning platforms and digital resources. However, there is limited research on the impact of technology on student learning outcomes and engagement. This study aims to explore the relationship between technology use and academic achievement among middle school students, as well as the factors that mediate this relationship.”

Examples of Background of The Study in Research Paper

Here are some examples of how the background of the study can be written in various fields:

Example 1: The prevalence of obesity has been on the rise globally, with the World Health Organization reporting that approximately 650 million adults were obese in 2016. Obesity is a major risk factor for several chronic diseases such as diabetes, cardiovascular diseases, and cancer. In recent years, several interventions have been proposed to address this issue, including lifestyle changes, pharmacotherapy, and bariatric surgery. However, there is a lack of consensus on the most effective intervention for obesity management. This study aims to investigate the efficacy of different interventions for obesity management and identify the most effective one.

Example 2: Antibiotic resistance has become a major public health threat worldwide. Infections caused by antibiotic-resistant bacteria are associated with longer hospital stays, higher healthcare costs, and increased mortality. The inappropriate use of antibiotics is one of the main factors contributing to the development of antibiotic resistance. Despite numerous efforts to promote the rational use of antibiotics, studies have shown that many healthcare providers continue to prescribe antibiotics inappropriately. This study aims to explore the factors influencing healthcare providers’ prescribing behavior and identify strategies to improve antibiotic prescribing practices.

Example 3: Social media has become an integral part of modern communication, with millions of people worldwide using platforms such as Facebook, Twitter, and Instagram. Social media has several advantages, including facilitating communication, connecting people, and disseminating information. However, social media use has also been associated with several negative outcomes, including cyberbullying, addiction, and mental health problems. This study aims to investigate the impact of social media use on mental health and identify the factors that mediate this relationship.

Purpose of Background of The Study

The primary purpose of the background of the study is to help the reader understand the rationale for the research by presenting the historical, theoretical, and empirical background of the problem.

More specifically, the background of the study aims to:

• Provide a clear understanding of the research problem and its context.
• Identify the gap in knowledge that the study intends to fill.
• Establish the significance of the research problem and its potential contribution to the field.
• Highlight the key concepts, theories, and research findings related to the problem.
• Provide a rationale for the research questions or hypotheses and the research design.
• Identify the limitations and scope of the study.

When to Write Background of The Study

The background of the study should be written early on in the research process, ideally before the research design is finalized and data collection begins. This allows the researcher to clearly articulate the rationale for the study and establish a strong foundation for the research.

The background of the study typically comes after the introduction but before the literature review section. It should provide an overview of the research problem and its context, and also introduce the key concepts, theories, and research findings related to the problem.

Writing the background of the study early on in the research process also helps to identify potential gaps in knowledge and areas for further investigation, which can guide the development of the research questions or hypotheses and the research design. By establishing the significance of the research problem and its potential contribution to the field, the background of the study can also help to justify the research and secure funding or support from stakeholders.

Advantage of Background of The Study

The background of the study has several advantages, including:

• Provides context: The background of the study provides context for the research problem by highlighting the historical, theoretical, and empirical background of the problem. This allows the reader to understand the research problem in its broader context and appreciate its significance.
• Identifies gaps in knowledge: By reviewing the existing literature related to the research problem, the background of the study can identify gaps in knowledge that the study intends to fill. This helps to establish the novelty and originality of the research and its potential contribution to the field.
• Justifies the research : The background of the study helps to justify the research by demonstrating its significance and potential impact. This can be useful in securing funding or support for the research.
• Guides the research design: The background of the study can guide the development of the research questions or hypotheses and the research design by identifying key concepts, theories, and research findings related to the problem. This ensures that the research is grounded in existing knowledge and is designed to address the research problem effectively.
• Establishes credibility: By demonstrating the researcher’s knowledge of the field and the research problem, the background of the study can establish the researcher’s credibility and expertise, which can enhance the trustworthiness and validity of the research.

Disadvantages of Background of The Study

Some Disadvantages of Background of The Study are as follows:

• Time-consuming : Writing a comprehensive background of the study can be time-consuming, especially if the research problem is complex and multifaceted. This can delay the research process and impact the timeline for completing the study.
• Repetitive: The background of the study can sometimes be repetitive, as it often involves summarizing existing research and theories related to the research problem. This can be tedious for the reader and may make the section less engaging.
• Limitations of existing research: The background of the study can reveal the limitations of existing research related to the problem. This can create challenges for the researcher in developing research questions or hypotheses that address the gaps in knowledge identified in the background of the study.
• Bias : The researcher’s biases and perspectives can influence the content and tone of the background of the study. This can impact the reader’s perception of the research problem and may influence the validity of the research.
• Accessibility: Accessing and reviewing the literature related to the research problem can be challenging, especially if the researcher does not have access to a comprehensive database or if the literature is not available in the researcher’s language. This can limit the depth and scope of the background of the study.

About the author

Muhammad Hassan

Researcher, Academic Writer, Web developer

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How to Write the Rationale of the Study in Research (Examples)

What is the Rationale of the Study?

The rationale of the study is the justification for taking on a given study. It explains the reason the study was conducted or should be conducted. This means the study rationale should explain to the reader or examiner why the study is/was necessary. It is also sometimes called the “purpose” or “justification” of a study. While this is not difficult to grasp in itself, you might wonder how the rationale of the study is different from your research question or from the statement of the problem of your study, and how it fits into the rest of your thesis or research paper. 

The rationale of the study links the background of the study to your specific research question and justifies the need for the latter on the basis of the former. In brief, you first provide and discuss existing data on the topic, and then you tell the reader, based on the background evidence you just presented, where you identified gaps or issues and why you think it is important to address those. The problem statement, lastly, is the formulation of the specific research question you choose to investigate, following logically from your rationale, and the approach you are planning to use to do that.

Table of Contents:

How to write a rationale for a research paper , how do you justify the need for a research study.

• Study Rationale Example: Where Does It Go In Your Paper?

The basis for writing a research rationale is preliminary data or a clear description of an observation. If you are doing basic/theoretical research, then a literature review will help you identify gaps in current knowledge. In applied/practical research, you base your rationale on an existing issue with a certain process (e.g., vaccine proof registration) or practice (e.g., patient treatment) that is well documented and needs to be addressed. By presenting the reader with earlier evidence or observations, you can (and have to) convince them that you are not just repeating what other people have already done or said and that your ideas are not coming out of thin air. 

Once you have explained where you are coming from, you should justify the need for doing additional research–this is essentially the rationale of your study. Finally, when you have convinced the reader of the purpose of your work, you can end your introduction section with the statement of the problem of your research that contains clear aims and objectives and also briefly describes (and justifies) your methodological approach. 

When is the Rationale for Research Written?

The author can present the study rationale both before and after the research is conducted. 

• Before conducting research : The study rationale is a central component of the research proposal . It represents the plan of your work, constructed before the study is actually executed.
• Once research has been conducted : After the study is completed, the rationale is presented in a research article or  PhD dissertation  to explain why you focused on this specific research question. When writing the study rationale for this purpose, the author should link the rationale of the research to the aims and outcomes of the study.

What to Include in the Study Rationale

Although every study rationale is different and discusses different specific elements of a study’s method or approach, there are some elements that should be included to write a good rationale. Make sure to touch on the following:

• A summary of conclusions from your review of the relevant literature
• What is currently unknown (gaps in knowledge)
• Inconclusive or contested results  from previous studies on the same or similar topic
• The necessity to improve or build on previous research, such as to improve methodology or utilize newer techniques and/or technologies

There are different types of limitations that you can use to justify the need for your study. In applied/practical research, the justification for investigating something is always that an existing process/practice has a problem or is not satisfactory. Let’s say, for example, that people in a certain country/city/community commonly complain about hospital care on weekends (not enough staff, not enough attention, no decisions being made), but you looked into it and realized that nobody ever investigated whether these perceived problems are actually based on objective shortages/non-availabilities of care or whether the lower numbers of patients who are treated during weekends are commensurate with the provided services.

In this case, “lack of data” is your justification for digging deeper into the problem. Or, if it is obvious that there is a shortage of staff and provided services on weekends, you could decide to investigate which of the usual procedures are skipped during weekends as a result and what the negative consequences are. 

In basic/theoretical research, lack of knowledge is of course a common and accepted justification for additional research—but make sure that it is not your only motivation. “Nobody has ever done this” is only a convincing reason for a study if you explain to the reader why you think we should know more about this specific phenomenon. If there is earlier research but you think it has limitations, then those can usually be classified into “methodological”, “contextual”, and “conceptual” limitations. To identify such limitations, you can ask specific questions and let those questions guide you when you explain to the reader why your study was necessary:

Methodological limitations

• Did earlier studies try but failed to measure/identify a specific phenomenon?
• Was earlier research based on incorrect conceptualizations of variables?
• Were earlier studies based on questionable operationalizations of key concepts?
• Did earlier studies use questionable or inappropriate research designs?

Contextual limitations

• Have recent changes in the studied problem made previous studies irrelevant?
• Are you studying a new/particular context that previous findings do not apply to?

Conceptual limitations

• Do previous findings only make sense within a specific framework or ideology?

Study Rationale Examples

Let’s look at an example from one of our earlier articles on the statement of the problem to clarify how your rationale fits into your introduction section. This is a very short introduction for a practical research study on the challenges of online learning. Your introduction might be much longer (especially the context/background section), and this example does not contain any sources (which you will have to provide for all claims you make and all earlier studies you cite)—but please pay attention to how the background presentation , rationale, and problem statement blend into each other in a logical way so that the reader can follow and has no reason to question your motivation or the foundation of your research.

Background presentation

Since the beginning of the Covid pandemic, most educational institutions around the world have transitioned to a fully online study model, at least during peak times of infections and social distancing measures. This transition has not been easy and even two years into the pandemic, problems with online teaching and studying persist (reference needed) . 

While the increasing gap between those with access to technology and equipment and those without access has been determined to be one of the main challenges (reference needed) , others claim that online learning offers more opportunities for many students by breaking down barriers of location and distance (reference needed) .  

Rationale of the study

Since teachers and students cannot wait for circumstances to go back to normal, the measures that schools and universities have implemented during the last two years, their advantages and disadvantages, and the impact of those measures on students’ progress, satisfaction, and well-being need to be understood so that improvements can be made and demographics that have been left behind can receive the support they need as soon as possible.

Statement of the problem

To identify what changes in the learning environment were considered the most challenging and how those changes relate to a variety of student outcome measures, we conducted surveys and interviews among teachers and students at ten institutions of higher education in four different major cities, two in the US (New York and Chicago), one in South Korea (Seoul), and one in the UK (London). Responses were analyzed with a focus on different student demographics and how they might have been affected differently by the current situation.

How long is a study rationale?

In a research article bound for journal publication, your rationale should not be longer than a few sentences (no longer than one brief paragraph). A  dissertation or thesis  usually allows for a longer description; depending on the length and nature of your document, this could be up to a couple of paragraphs in length. A completely novel or unconventional approach might warrant a longer and more detailed justification than an approach that slightly deviates from well-established methods and approaches.

Consider Using Professional Academic Editing Services

Now that you know how to write the rationale of the study for a research proposal or paper, you should make use of Wordvice AI’s free AI Grammar Checker , or receive professional academic proofreading services from Wordvice, including research paper editing services and manuscript editing services to polish your submitted research documents.

You can also find many more articles, for example on writing the other parts of your research paper , on choosing a title , or on making sure you understand and adhere to the author instructions before you submit to a journal, on the Wordvice academic resources pages.

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Doctorate of Business Administration: 10 Tips for DBA Research

• August 21, 2024

Table of Contents

Academic research is at a crossroads between tradition and innovation. The landscape is rapidly transforming, as technological advances shift educational structures and bring up tough questions on ethical integrity. For sure, it’s an exciting time to study a Doctorate of Business Administration and to do DBA Research.

This blog post delves into 10 tips to navigate the research portion of your DBA, offering insights into the evolving nature of research and its implications for scholars and practitioners alike.

Be Smart When Embracing Technology

In the academic universe, change is not just a constant; it’s a necessity . We’re on a journey where the old intersects with the new, where the traditional academic rigor meets the swift currents of technological innovation.

There’s been a significant leap forward in the tools available to researchers. Software like Mandalay represent a leap forward in DBA research efficiency, automating citation management and data organization. These advancements save researchers valuable time, allowing them to focus more on analysis and less on administrative tasks.

Learn to Balance Tech With Tradition

There’s a sort of struggle for balance between technology and fundamentals. Remember that while it streamlines DBA research, technology cannot replace the foundational understanding of research principles . 

A profound grasp of methodology and critical thinking remains essential. It ensures that scholars can effectively leverage new tools without compromising the integrity of their work.

Originality Triumphs Everything in DBA Research

There it is, the elephant in the room: plagiarism. With AI tools in hand, the line into plagiarism is blurrier than ever. That’s why it’s crucial for researchers to use technology responsibly , ensuring that their work maintains originality and credibility.

Technology should enhance, not replace, the foundational bedrock of scholarly inquiry. Aim for originality.

Develop Presentation Skills

Parallel to technological advancements, the art of presenting and communicating DBA research has gained significance. In today’s digital age, scholars must not only produce original research but also possess the skills to present it effectively. 

Scholars must bring fresh perspectives and critical analysis to their work. They need a deep engagement with their subject matter.

What’s more, they need dynamic presentation skills . Effective communication is key in presenting research. Scholars should strive to create engaging and clear presentations, showcasing their findings with confidence and clarity.

A well-structured presentation highlights the importance and implications of research findings. Clear communication helps to convey complex ideas effectively, making the research accessible and impactful.

As Structures Change, Learn To Adapt

Doctoral research programs are evolving to be more accommodating to working professionals, offering structured pathways that expedite the journey to a doctoral degree without sacrificing academic rigor.

For example, the shift towards Doctoral Research Projects (DRPs) indicates a broader trend in education towards more flexible and accessible learning models, tailored to the needs of today’s scholars and professionals.

Therefore, the future of DBA research education lies in its ability to be adaptable, accessible, and aligned with the evolving demands of the academic and professional world.

Exercise Your Critical Thinking Skills

Critical thinking is at its most important. When you dive into literature review, make it meaningful. It lays the groundwork for meaningful research, providing the context and framework necessary for insightful analysis and discovery.

Critical thinking and analytical skills are the backbone of DBA research , enabling scholars to evaluate findings accurately and contribute valuable insights to their field.

Value Face-to-Face Interactions for your DBA Research

Direct interactions, such as oral presentations and defenses, are crucial for assessing the authenticity and depth of DBA research They underscore the importance of personal engagement in the digital age.

Remember – no matter how much technology can help you assemble an articulate paragraph, it can’t do anything for you during an oral presentation. 

Foster Collaborative Relationships

A collaborative relationship between students and advisors is fundamental to research success, as it fosters an environment of support, guidance, and mutual respect.

Reach out to those around you. Work together, request feedback, and learn from each other. There’s a lot of room to grow, and the people around you are the best source of growth .

Uphold Ethical Standards of DBA Research

Maintaining academic rigor and ethical standards is paramount. It ensures that the integrity of scholarly work remains untarnished.

Adhere to ethical DBA research practices , including thorough and accurate citations. The credibility and reliability of academic work have high standards, and you should strive to meet them.

Look Forward to Innovation

The future of DBA research is a blend of tradition and innovation , where integrating new technologies and methodologies enhances the depth and reach of scholarly inquiry. By embracing these changes while steadfastly upholding the principles of rigorous and ethical research, the academic community can confidently navigate this evolving landscape and contribute meaningful advancements to the world of knowledge.

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  Global Journal of Educational Research Journal / Global Journal of Educational Research / Vol. 23 No. 3 (2024) / Articles (function() { function async_load(){ var s = document.createElement('script'); s.type = 'text/javascript'; s.async = true; var theUrl = 'https://www.journalquality.info/journalquality/ratings/2408-www-ajol-info-gjedr'; s.src = theUrl + ( theUrl.indexOf("?") >= 0 ? "&" : "?") + 'ref=' + encodeURIComponent(window.location.href); var embedder = document.getElementById('jpps-embedder-ajol-gjedr'); embedder.parentNode.insertBefore(s, embedder); } if (window.attachEvent) window.attachEvent('onload', async_load); else window.addEventListener('load', async_load, false); })();  

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Article Details

© Bachudo Science Co. Ltd. This work is licensed under the creative commons Attribution 4.0 International license.

Ekpo Effiom Eyo

 Institute of Public Policy and Administration, University of Calabar, Calabar,                                  Nigeria

Ekpenyong Enoh Bassey

Department of Educational Management, University of Calabar,                                                      Calabar, Nigeria

Eyo Victoria Effiom

History and International Studies, University of Calabar, Calabar, Nigeria

Main Article Content

Working conditions and teacher's productivity in public secondary schools in calabar metropolis, cross river state, nigeria.

The study investigated the relationship between working conditions and teachers productivity in public secondary schools in Calabar metropolis, Cross River State, Nigeria. The study tested a null hypothesis.  Ex-post facto research design was adopted for the study. A sample of 260 teachers were randomly selected for the study. The selection was done using stratified random sampling technique and simple random sampling technique in order to give equal opportunity to all the members of the population to be selected. Working Conditions and Teachers' Productivity Questionnaire (WCTPQ) was the instrument used for the data collection. The instrument was subjected for validation. The reliability estimate of the instrument was established through trial test and the reliability co-efficient obtained using Crobach Alpha method. Pearson product moment correlation analysis was used for data analysis. The hypothesis was tested at .05 level of significance with relative degrees of freedom. The result revealed that there is a significant relationship between working conditions and teachers productivity. Based on this finding, it was recommended that government and schools management should provide and implement conducive working conditions to the teacher to enhance their productivity.

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Journal Identifiers

• Open access
• Published: 22 August 2024

Expression and clinical significance of CLDN7 and its immune-related cells in breast cancer

• Xiaojie Fan 1 ,
• Aifeng Qi 2 ,
• Meng Zhang 1 ,
• Ying Jia 1 ,
• Dandan Han 1 &
• Yueping Liu 1  

Diagnostic Pathology volume  19 , Article number:  113 ( 2024 ) Cite this article

12 Accesses

Metrics details

CLDN is a core component of tight junctions (TJs). Abnormal expressions of CLDNs are commonly detected in various types of tumors. CLDNs are of interest as a potential therapeutic target. CLDNs are closely associated with most cancers of epithelial origin, especially when CLDN7 promotes cancer cell metastasis, such as in gastric, cervical, and ovarian cancers.Its expression and prognosis in breast cancer (BC) remain unknown.The purpose of this study was to investigate the expression pattern of CLDN7 and related immune factors in BC and shed light on a better therapeutic avenue for BC patients.

The cBioPortal, GEPIA, and TCGA databases were used to comprehensively assess the expression of CLDN7 in BC. The Kaplan-Meier Plotter (KMP) database was applied to examine the relationship among the CLDN7 overexpression (OE), prognosis, and overall survival (OS) of BC patients. Immunohistochemical staining was performed on 92 BC tissue samples and 20 benign breast tumors to verify the expression level of CLDN-7 protein and its correlation with clinicopathological features and prognosis. TIMER2.0 was used to analyze the correlation between the CLDN7 OE and immune gene activation using BC-related transcriptomic data. Enrichment analyses of CLDN7-related immune pathways were conducted using online databases. The risk of expression of CLDN7-related immune genes was assessed and differentially expressed (DE) genes were included in the construction of the risk prognosis nomogram.

Both database analysis and clinical sample validation results showed that CLDN7 was significantly overexpressed (OE) in BC, and the OE was correlated with poor DFS in BC patients ( p  < 0.05). TIMER2.0 analysis indicated that CLDN7 OE was negatively associated with the activation of B-cells, CD4 + T-cells, and CD8 + T-cells but positively with the M 0 macrophages. Pathway enrichment analysis suggested that CLDN7-related immune factors were mostly involved in the NF-κB and T-cell receptor (TCR) signaling pathways. Univariate Cox regression was used to analyze the correlation between 52 CLDN7 related genes and OS, and 22 genes that are related to prognosis were identified. Prognostic genes were included in the prognostic nomogram of BC with a C-index of 0.76 to predict the 3-year and 5-year OS probabilities of BC individuals.

Conclusions

These findings provide evidence for the role of CLDN7-linked tumor immunity, suggesting that CLDN7 might be a potential immunotherapeutic target for BC, and its association with immune markers could shed light on the better prognosis of BC.

Introduction

Breast cancer (BC) is one of the most frequently diagnosed carcinomas in women worldwide, ranking second highest in terms of the mortality rate, which has been rapidly increasing every year [ 1 ]. Pathologically, BC represents a highly heterogeneous cancer subtype that varies from patient to patient. Notably, the prognosis of BC patients primarily relies on the patient’s immunity [ 2 ]. It is found that BC pathology is associated with a robust infiltration of immune-active T-cells into the lesion area, including the stroma. While the population of infiltrating CD8 + T-cells is significantly correlated with the immune escape capacity of cancer cells, the rate of infiltration of both CD8 + and CD4 + T-cells indicates the prognosis of the patient [ 3 ]. Importantly, macrophages contribute to roughly 50% of the invasive immune cells and are mostly responsible for promoting the anti-tumor defense mechanism [ 4 ]. Therefore, there is an urgent requirement to identify diagnostic as well as prognostic indicators to guide personalized therapy to BC patients.

Despite the recent advancement in BC diagnosis and treatment strategies, cancer recurrence and metastasis remain the major concerns for patient survival. To improve the precision of BC therapy, novel druggable targets have been discovered exploiting the factors involved in the intracellular communications and epithelial-mesenchymal transition (EMT) process. Pathological alterations in the expression of protein factors regulating various cell-cell adhesion ports, including the gap junction (GJ), tight junction (TJ), desmosomes, and adhesive junction, can induce EMT. Amongst them, abnormal expressions of several TJ-related claudins (CLDNs) are commonly detected in various types of tumors. CLDNs contain 27 families of transmembrane proteins [ 5 ]. Depending on the variations in protein sequences, CLDNs can be divided into two types, namely the classical (e.g., CLDN1-10, 14, 15, 17, and 19) and atypical (e.g., CLDN11-13, 16, 18, 20–24) [ 6 ]. CLDNs range from 20 to 34 kDa in size, consisting of N- and C-terminal cytoplasmic, four transmembrane, and two extracellular ring domains. The C-terminus of CLDN proteins are diverse in their sequences and lengths and also harbors sites (serine, threonine, and tyrosine) for the post-translational phosphorylation that regulates the protein’s structure and function. It is shown that dysregulated expression and protein phosphorylation could result in tumorigenesis and metastasis in the later stage.

Therefore, in this study, we investigated the expression pattern of CLDN7 and related immune factors in BC by bioinformatic analysis and assay to shed light on a better therapeutic avenue for BC patients.

Materials and methods

Downloading the database information.

The cBioPortal database ( https://www.cbioportal.org/ ) was exploited to study the CLDN7 gene mutation analysis in various types of tumors. The Human Protein Atlas (HPA) ( https://www.proteinatlas.org/ ) was used to analysis CLDN7 cellular localization in BC cell lines (MCF-7) and expression level in BC samples. The Kaplan-Meier Plotter (KMP) ( https://kmplot.com/analysis/index.php?p=service&cancer=breast ) was employed to perform the correlative analyses among the CLDN7 expression profile and overall survival (OS: the period from the date of diagnosis to the date of recorded death) rate, and recurrence-free survival (RFS: the period from the date of curative surgery to the time of recurrence or death) rate in BC patients. Further, KMP was used to analyze the association between CLDN7 expression and RFS of BC molecular subtypes including Luminal A, Luminal B, HER2 enriched and TNBC. The Cancer Genome Atla (TCGA) dataset ( https://portal.gdc.cancer.gov/ ) containing information on 1109 BC and 113 healthy controls was also used in the correlation analysis between the clinicopathological features and corresponding CLDN7 expressions. The differential expression (DE) of CLDN7 between BC and normal tissues was analyzed using the limma package (R software).

Pathological data of clinically verified samples

Paraffin-embedded tissue samples from 92 BC and 20 benign breast tumors (controls) cases including 8 intraductal papilloma and 12 fibroadenoma were selected from the patients who received radical mastectomy (RM) surgeries in the Hebei Medical University (HMU; Fourth Hospital, Pathology department) from June 2016-17 for a standardized tissue pretreatment [ 7 ]. Follow-up data of medical records showed that these patients were never preoperatively treated with any of the radio-chemotherapy, targeted, or immunotherapy. All the above samples were obtained with informed consent and signed by the subjects or their family members. The study scheme has been reviewed and approved by the Ethics Committee of the hospital (ethics review No. 2021KY1421).

Expression of CLDN7 in clinically verified samples

Immunohistochemical (IHC) analysis of tissue sections was performed following the EnVision method using a primary anti-CLDN7 (Abcam, ab207300, dilution 1:200) and corresponding HRP-conjugated secondary antibodies (Mixin Biological). The antibody staining was visualized by a DAB Dye solution (MaxVision; Mixin Biological). The cytoplasmic and/or cytomembrane localizations of CLDN7 were confirmed by brown-yellow staining in positive control samples. Based on the IHC staining intensities and percentages, a semi-quantitative scoring system (3 for strong, 2 for moderate, 1 for weak, and 0 for no detected expression) was adopted for assessing CLDN7 expression levels. Furthermore, proportions of CLDN7-positive tumor cells were scored as 3 for 51–100%, 2 for 11–50%, 1 for 1–10%, and 0 for no positive cell staining. Cases with a staining score of 3 (51–100%) and medium to strong (2–3) staining intensity were characterized as high expression CLDN7 patients [ 8 ]. The IHC images were captured at 100× magnification under a light microscope and scored by two experienced pathologists.

Signal pathway enrichment

The correlation between immune gene activation and CLDN7 expression levels was analyzed by TIMER2.0 using the BC transcriptome profiles. The CLDN7-related immune modulators were explored in TISIDB, an online integrated database ( http://cis.hku.hk/TISIDB/ ). Immuno-suppressive and stimulants genes that had been significantly correlated with the expression of CLDN7 were selected for this analysis ( P  < 0.05, Spearman’s correlation). We uploaded the CLDN7 expression regulating immunomodulators to the Cancer Genomics Student Biology (CGSB) web portal ( www.cbioportal.org ). By using this network module, 50 genes changed at the same time were queried. The WebGestalt toolkit ( http://www.webgestalt.org/ ) was applied to the functional enrichment of immune modulators for the KEGG pathway analyses.

Risk assessment

The Cox model was applied to the analysis of variables for the establishment of a prognostic risk model of BC, guided by the correlative interactions between CLDN7 and other immune-associated genes. After the initial selection, the prognostic index (risk-score) was derived using the formula: risk-score = a1b1 + a2b2+… + aibi, where a1 refers to the expression level of individual genes, and b1 is the risk coefficient of each gene from the Cox model. The KM survival curve, log-rank test, and Cox analysis were employed to evaluate the relationship among immune-related gene characteristics, clinical features, and OS. In this analysis, we included the factors like gender, age, cancer staging (TNM staging), and other related parameters. The R language ROC software package was used to assess the accuracy of the risk-score.

Line graph construction

The prognosis of BC patients was assessed by combining the patient’s risk-score with the clinical characteristics. A standard calibration curve was constructed to visualize the deviation of the predicted probability from the observed one for individual patients. The consistency index (C-index) indicated the predictive accuracy of the nomogram.

Statistical analysis

SPSS v26.0 and R v4.0.2 software packages were used for the data analysis and GraphPad Prism 9 was used for plotting the graphs. Measurement data were presented as ‾χ ± s, and between-group comparisons were performed using two independent sample t-tests. Count data were expressed as percentages and cases. The patients’ survival curves were constructed by the KM method, while the survival rates of the patients were compared by the log-rank test. Any statistical correlations between the CLDN7 expression level and clinicopathologic features of BC patients were determined by the chi-squared (χ 2 ) test. Spearman’s correlation analysis indicated if there was any correlation between the population of tumor-infiltrating immune cells and the modulation of CLDN7 expression. P  < 0.05 was considered the threshold for any statistically significant differences.

Altered expressions of CLDN7 in BC tissues

Analysis of the cBioPortal tumor database showed that the CLDN7 gene could be mutated, downregulated, and even deleted in BC and many other cancers (Fig.  1 ). Consistent with the HPA database, immunofluorescence (IF) results of the CLDN7’s subcellular localization indicated its preferential abundance in the cytoplasmic membranes and/or cytomembrane in the MCF-7 cells (Fig.  2 ). Furthermore, IHC analysis confirmed overexpression of CLDN7 in BC tissues (Fig.  3 ).

Mutation, amplification and deletion of CLDN7 in multiple cancers from cBioPortal tumor database

Immunofluorescence detection of CLDN7 in MCF-7 breast cancer cells from The Human Protein Atlas database

Expression of CLDN7 in breast cancer tissues from The Human Protein Atlas database

Correlation between the CLDN7 expression and prognosis of BC

The KMP analysis revealed that the BC patients with CLDN7 overexpression (OE) had poor OS than those with the CLDN7 low expression profile (HR = 1.24, P  = 0.026; Fig.  4 A). Further analysis of the RFS of BC patients exhibited significantly reduced rates in cases with the CLDN7 OE than those with the low expression of CLDN7(HR = 1.16, P  = 0.0048; Fig.  4 B). Correlation analysis between the expression level of CLDN7 and survival prognosis by molecular subtypes showed no correlation between the CLDN7 expression modulation and the RFS rates of Luminal A (HR = 0.92, P  = 0.43; Fig.  4 C) and Luminal B (HR = 0.89, P  = 0.2; Fig.  4 D). The rate of RFS was significantly lower in BC patients overexpressing both HER2 and CLDN7 compared to their low-expression counterparts (HR = 1.47, P  = 0.0018; Fig.  4 E). Notably, the RFS of the triple-negative BC (TNBC) subtype with the CLDN7 OE was significantly lower than the respective controls (HR = 1.47, P  = 0.00046; Fig.  4 F).

The relationship between the expression level of CLDN7 in breast cancer from Kaplan-Meier Plotter database. (A-B) highly expressed CLDN7 displayed shorter (A) OS, and (B) RFS time. (C-F) Subtype analysis showed that (C) luminal A, (D) luminal B, (E) HER2 enriched, and (F) TNBC

Correlation between CLDN7 expression and pathological features in BC tissues of TCGA database

TCGA-BC transcriptomic analysis using the limma package showed significant differences in CLDN7 expressions between the BC and control tissues ( P  < 0.05; Fig.  5 ). Moreover, correlation analysis between the CLDN7 expression and pathological features in 908 BC samples (TCGA) with complete clinical information revealed that the altered expression of CLDN7 could be associated with expressions of the estrogen receptor coding gene ESR1 and the human epidermal growth factor receptor encoding gene ERBB2 (All P  < 0.05; Table  1 ).

Expression of CLDN7 in normal and tumor of breast tissues

Expression of CLDN7 in clinical samples

Pathological expressions of CLDN7 in 92 clinically confirmed BC samples are shown in Table  2 . CLDN7 levels were significantly higher in BC samples than that in the benign tumor samples ( P  < 0.05; Fig.  6 ). Besides, almost all subtypes of cancer cells exhibited CLDN7 OE-positive cells than that in the control samples ( P  < 0.05; Fig.  7 A-B). The KM survival analysis further verified that the RFS was drastically reduced in BC patients with CLDN7 OE ( P  < 0.05;Fig.  7 C).

Expression of CLDN7 in benign of the breast and breast cancer tissue detected by IHC (larger map, x100; small icon, x400). (A) Weak staining for CLDN7 in benign breast tumor (B) Weak staining for CLDN7 in BC (C) Moderate staining for CLDN7 in BC (D) Strong staining for CLDN7 in BC

Expression level of CLDN7 in breast cancer tissues and its relationship with patients’ RFS. (A) Quantitative analysis of CLDN7 in benign breast tumor tissue and breast cancer tissue (B) Expression levels of CLDN7 in subtypes of breast cancer (C) CLDN7 expression and RFS analysis in breast cancer patients

Correlation between CLDN7 expression and immune cell activation

The TIMER2.0 analysis revealed that the rate of immune cell infiltration into the tumor was increased in association with CLDN7 OE in BC samples than in the controls (Fig.  8 ). The CLDN7 OE was negatively correlated with the activation of B-cells, and CD4 + /CD8 + T-cells but positively with the M 0 macrophages.

Correlation between CLDN7 expression and immune cell infiltration in breast cancer tissues. (A) CLDN7 expression was correlated with B cells (B) CLDN7 expression was correlated with CD4 + T cells (C) CLDN7 expression is correlated with M0 macrophages (D) Correlation between CLDN7 expression and CD8 + T cells (Pearson correlation test)

Enrichment analyses

Analysis of the TISIDB identified CLDN7-associated 15 immunosuppressive ( BTLA, CD274, CD244, CD160, CD96, CSF1R, CTLA4, KDR, HAVCR2, IDO1, PDCD1, PDCD1LG2, TIGIT, PVRL2 and TGFBR1 ) and 37 immunostimulatory ( C10ORF54, CD80, CD70, CD48, CD27, CD86, CD28, CD40LG, ENTPD1, CXCL12, CXCR4, ICOSLG, ICOS, IL2RA, IL6, IL6R, KLRK1, KLRC1, LTA, MICB, NT5E, PVR, TMEM173, TNFSF4, TNFRSF8, TNFRSF14, TNFRSF9, TNFRSF13B, TNFRSF13C, TNFSF14, TNFRSF17, TNFRSF18, TNFSF9, TNFSF13, TNFSF13B, ULBP1 and TNFSF15 ) genes(Fig.  9 A). The top 50 genes associated with these immunomodulatory functions were analyzed using cBioPortal. The KEGG analysis revealed that these genes were mainly enriched in the NF-κB and T-cell receptor (TCR-mediated)signaling pathways (Fig.  9 B).

Identification and analysis of CLDN7 gene-related immunomodulators. ( A ) Heat map of immunosuppressive gene correlation with CLDN7 gene in breast cancer (left) ; Heat map of immunostimulatory gene correlation with CLDN7 gene in breast cancer (right) (B) Enrichment of CLDN7-related immunomodulatory genes and the signaling pathways involved in 50 closely related genes

Assessment of the prognostic value of CLDN7-related immunomodulators in BC

Univariate Cox regression analysis of the correlation between the expression of immunomodulatory genes and the OS in 1109 BC and 113 controls (TCGA) identified 22 genes, including 5 high-risk and 17 low-risk, that could have significant prognostic implications to BC pathogenesis (Fig.  10 A). Furthermore, a multivariate Cox regression analysis of risk-scores was used for the construction of the prognostic model. The KM survival curve indicated that low-risk-score subjects had longer survivals than those with high-risk-scores ( P  < 0.001; Fig.  10 B). As shown in Fig.  10 C, the risk-score had a significant correlation with the OS in BC patients in the univariate Cox regression model (HR = 3.089; 95%CI = 1.996–4.779; P  < 0.001). Consistently, the multivariate Cox regression model showed a similar trend in BC survival (HR = 2.758; 95%CI = 1.771–4.293; P  < 0.001; Fig.  10 D). Furthermore, the AUC of the risk-score for predicting 3-year OS in BC was 0.715, and the risk-score plus clinical feature for predicting 3-year OS in BC was 0.819 (Fig.  10 E). Likewise, the AUC of the risk-score for predicting 5-year OS in BC was 0.713, and that for the risk-score plus clinical feature was 0.793 (Fig.  10 F).

Prognostic value of CLDN-7-related immunomodulatory genes in breast cancer. (A) Forest map of risk scores of genes associated with breast cancer prognosis (B) Kaplan-Meier survival curve of prognosis model constructed by risk score (C) A univariate Cox regression analysis of risk scores for overall survival in the show (D) Multivariate Cox regression analysis of risk scores for breast cancer with respect to overall survival (E) 3-year ROC curve of breast cancer risk score (F) 5-year ROC curve of breast cancer risk score

Based on the results of Cox regression, a prognosis histogram of BC was constructed to predict individual survival probability by weighing the risk-score, gender, age, clinical staging, and TNM staging (Fig.  11 A). The calibration curve was used to calibrate the line graph, which established a relationship between the probability of survival rate predicted by the line graph (solid line) and the concept reference line (dashed line) (Fig.  11 B-C). The dashed line at 45 °C represents the perfect agreement between the line graph prediction and the true probability. By using the C-index to assess the predictive differential power of the line graph, the experiment showed agreement between the prediction probability of the histogram and the actual observation of death. The C-index of the prognosis line graph was 0.85.

Prognosis histogram of breast cancer ( A ) Histogram of 1-year, 3-year, and 5-year survival probability of individual breast cancer patients (B) 3-year calibration curve for breast cancer patients (C) Calibration curve for 5-year survival of breast cancer patients

BC remains the most frequently diagnosed malignancy in women. Several high-efficiency antibodies targeting the immune checkpoints in BC cells were approved by FDA [ 9 , 10 , 11 ]for treating BC. However, complete eradication of carcinoma by tumor-specific T-cells involves a highly orchestrated and complex mechanism [ 12 ], and the efficacy of immunotherapy majorly depends on the successful completion of each in the whole process. As a result, it’s crucial to develop therapeutically more effective drug design as well as a precise screening of suitable BC patients for the intended treatment. However, precision biomarkers, capable of indicating a patient’s immune status and prognosis, would be of great value in improving treatment decisions for BC patients.

CLDNs, together with occlusion proteins and cell adhesion molecules comprise a tightly connected transmembrane complex that functions as a paracellular barrier and intracellular signaling port in regulating the proliferation, differentiation, and apoptosis of epithelial cells [ 13 ]. It’s shown that CLDN is closely associated with most cancers of epithelial origin, especially when CLDN7 promotes cancer cell metastasis, such as in gastric, cervical, and ovarian cancers [ 14 , 15 , 16 ]. However, the CLDN1 OE is shown to induce epithelial-to-mesenchymal metastasis, while CLDN7 acts as a tumor suppressor in colorectal cancer [ 17 ]. Thus, CLDN7 can simultaneously play both tumor-promoting and inhibitory roles in human malignancies, depending on the type of tumor.

In this study, cBioPortal, HPA, and KMP databases were employed to analyze the CLDN7 expression profile in BC tissues, which showed a significant upregulation in CLDN7 expression and correlated with adverse effects on OS and DFS rates in BC. The TCGA-BC cohort study has demonstrated that CLDN7 OE is strongly correlated with that of ESR1 and ERBB2. Further analysis of clinical samples revealed that the CLDN7 protein level was correlated with the HER2 level and lymph node as well as metastasis and distant metastases. HER2 (ERBB2, neu) status assessment is routinely used in the molecular diagnosis of BC. Analysis of a large cohort of BC patients has found that HER2 OE could be associated with poor prognosis and poor response to chemotherapy [ 18 ]. Notably, lymph node metastasis is the most critical indicator of OS and DFS in BC patients. Accurate evaluation of lymph node involvement is an important component of BC staging [ 19 ]. Moreover, EMT plays an important role in promoting distant metastasis and tumor infiltration in BC [ 20 ]. Therefore, it is speculated that CLDN7 may have a pro-tumor role in BC pathogenesis.

Additionally, we used the TIMER2.0 database to explore the correlative relationship between the CLDN7 OE and immune cell infiltration in BC. We found that the CLDN7 OE was negatively associated with the activation of B-cells and CD4 + /CD8 + T-cells but positively with the abundance of the M 0 macrophages. Analyses of the TISIDB and cBioPortal indicated that CLDN7-related expression of immunomodulatory genes was mainly enriched in the NF-κB and TCR signaling pathways. Corresponding studies have found that CLDN7 is involved in the inflammatory responses through NF-κB signaling, and the addition of NF-κB inhibitors can inhibit the increase of CLDN7 level [ 21 , 22 ]. The NF-κB signaling is involved in tumor angiogenesis and the transcriptional activation of tumorigenic chemokines. Thus, hyperactivation of the NF-κB signaling could cause dysregulated expression of several immune-modulatory factors, including cytokines, chemokines, adhesion factors, and inhibitors of apoptosis [ 23 ]. Hence, the role of NF-κB signaling in immunotherapy has been extensively investiagated [ 24 , 25 , 26 ]. An NF-κB inhibitor (DHMEQ) has demonstrated effective inhibition of both early and late-stage metastases [ 27 , 28 ]. Inhibitors and antibodies of the NF-κB signaling pathway factors have been targeted to neutralize immune checkpoints in clinical trials of lung cancer [ 24 ]. In summary, CLDN7 inhibitors can be predicted biologically.

The opening up of high-throughput gene expression datasets has immensely contributed to the discovery of potential biomarkers of BC to improve the prognosis [ 29 , 30 , 31 ]. A genome-wide gene expression profile analysis of 6,415 BC patients’ samples from 22 public cohorts has established an immune-related prognostic scoring (IRPS) system to correlate the OS outcomes with immunophenotypic factors in BC patients. Chemotherapy has been shown to increase the IRPS, indicating that chemotherapeutics can stimulate the immune signal spectrum in BC patients, and is sufficient to predict a patient’s response to the immune-checkpoint inhibitors [ 32 ]. Han et al. have analyzed the gene expression profiles of BC samples through cancer gene mapping and in vitro studies [ 33 ] showing that DEs of immune-related genes are closely associated with BC recurrence. The study has also constructed prognostic signatures for eight immune genes that might be involved in increasing the risk of relapse in subgroups of BC patients [ 33 ]. Similarly, our study established an immune genetic profile of BC using CLDN7-related immunomodulators. Risk-scores derived from genetic traits were significantly associated with the OS rate in BC patients. Most immune genes, integrated into the prognostic signals, are involved in the regulation of T-cell activation, highlighting the importance of T-cell-mediated immunity in CLDN7 overexpressing BC patients. Finally, we constructed a personalized prognostic column graph with a C-index of 0.85. Our results suggest that risk-score analysis from the DE profile of CLDN7-related immunomodulatory genes can stratify the risk groups, and the discovery of intuitive expression of CLDN7 in BC tissues may improve the validation of BC prognosis.

In conclusion, these results suggest that CLDN7 may play a critical role in the regulation of tumor immune-microenvironment. Prognostic signals from the CLDN7-related immunomodulators can independently predict the OS rate in BC. More prospective studies would require to further validate the clinical application of this prognostic biomarker in the personalized therapy of BC.

Data availability

No datasets were generated or analysed during the current study.

Abbreviations

Human Protein Atlas

Kaplan-Meier Plotter

Overall Survival

Recurrence-Free Survival

The Cancer Genome Atla

Differential Expression

Immunohistochemical

Cancer Genomics Student Biology

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All authors sincerely thank Hebei Medical University (HMU; Fourth Hospital, Pathology department) for providing experimental equipment and experimental platform for this research.

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Research Designer: Xiaojie Fan and Meng Zhang; Data analysts: Aifeng Qi; Experimenters: Ying Jia, Shi Li, Dandan Han; Writer: Xiaojie Fan. Instructors and reviewers of the manuscript: Yueping Liu. The finished manuscript has been reviewed and granted by all authors.

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Fan, X., Qi, A., Zhang, M. et al. Expression and clinical significance of CLDN7 and its immune-related cells in breast cancer. Diagn Pathol 19 , 113 (2024). https://doi.org/10.1186/s13000-024-01513-1

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Received : 22 April 2024

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DOI : https://doi.org/10.1186/s13000-024-01513-1

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