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Who Killed Yew?
Murder and Mitosis
By Marlee B. Marsh
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The purpose of this case is to teach introductory college biology students the basic process of mitosis, focusing on the fundamental cellular processes that occur during each of the stages-prophase, prometaphase, metaphase, anaphase, telophase and cytokinesis. It would also be appropriate for AP Biology students. The case is framed around solving a murder. The murder plot involves a naturally-occurring poison derived from Yew trees, known as paclitaxel. Paclitaxel is a mitotic inhibitor that works by inhibiting the depolymerization of microtubules so that the cell is arrested in metaphase. At the end of the case, students will be able to describe the basic process of mitosis, including the fundamental processes that occur in each stage. The discovery of paclitaxel led to the development of the chemotherapeutic drug, Taxol ®, and the case concludes by having students think about the correlations between poisons and chemotherapies. The case involves the use of videos, one of which was made by the author for this case, and can be used in a flipped classroom.
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- Explain the basic function and process of mitosis in animal cells at the introductory biology level.
- Recognize, draw and label interphase, prophase, prometaphase, metaphase, anaphase, telophase and cytokinesis.
- Understand and describe the role of microtubules in the process of mitosis.
- Learn what a mitotic inhibitor is, how it may work, and the outcome of inhibiting mitosis.
- Understand the basic science behind chemotherapy as a cancer treatment and why there can be side effects associated with chemotherapeutic treatment.
mitosis; yew; microtubule; cell cycle; paclitaxel; poison; cytoskeleton; chemotherapy; Taxol; Taxus; mitotic inhibitor; cancer;
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EDUCATIONAL LEVEL
High school, Undergraduate lower division
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TYPE/METHODS
Teaching Notes & Answer Key
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Teaching notes are intended to help teachers select and adopt a case. They typically include a summary of the case, teaching objectives, information about the intended audience, details about how the case may be taught, and a list of references and resources.
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Materials & Media
Supplemental materials.
- Mitosis This video explains the molecular mechanism of mitosis. Running time: 6:09 min. Produced by NDSU Virtual Cell Animations Project, 2011.
- Who Killed Yew? This video explains how the poison paclitaxel inhibits microtubule function during mitosis. Running time: 1:56 min. Created by Marlee B. Marsh for the National Center for Case Study Teaching in Science, 2014.
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Who Killed Yew Murder and Mitosis answers
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Who Killed Yew Case Study Answer Key Case Solution & Analysis
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IMAGES
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COMMENTS
Terms in this set (9) taxines. chemicals found in the Yew plant that are toxic because they disrupt the process of mitosis. mitotic inhibitor. a drug that hinders the process of mitosis. microtubules. the cytoskeletal element that is most susceptible to mitotic inhibitors. chromatin. the complex of DNA and proteins that forms the chromosomes.
The case is framed around solving a murder. The murder plot involves a naturally-occurring poison derived from Yew trees, known as paclitaxel. Paclitaxel is a mitotic inhibitor that works by inhibiting the depolymerization of microtubules so that the cell is arrested in metaphase. At the end of the case, students will be able to describe the ...
It is a case study called Who killed Yew? Murder and Mitosis . It revi... View more. Course. Biology Of Cancer (BIO 5763) 25 Documents. Students shared 25 documents in this course. University University of Central Oklahoma. Academic year: 2019/2020. Uploaded by: Anonymous Student.
Can cancer patients be given chemotherapy indefinitely. No, it would kill them. Study with Quizlet and memorize flashcards containing terms like What type of plan could be carried out by adding the seeds of Taxus baccata to pecan pie?, what's a mitotic inhibitor, Why did Dr. Beckham only have mild symptoms and more.
NATIONAL CENTER FOR CASE STUDY TEACHING IN SCIENCE Who Killed Yew? Murder and Mitosis by Marlee B. Marsh Department of Biology Columbia College, Columbia, SC Part I - The Intruder Te intruder entered the kitchen of the upscale restaurant at 2:43am. All was quiet. All was dark. Te intruder moved quickly, but he was not in a rush.
4. The skin and bone marrow have cells that divide rapidly. 5. Taxol would prevent normal, healthy cells from replicating. Thus, hair loss and low blood counts would occur. 6. Taxines from the yew tree are a mixture of poisons. When parts of the yew tree are ingested, the taxines include the compounds paclitaxel and taxine B.
When parts of the yew tree are ingested, the taxines include the compounds paclitaxel and taxine B. Te taxine B is actually what causes death (within hours) of those poisoned. It interferes with calcium channels in the heart and causes cardiac arrest, which can be fatal, as it was in the case of the governor.
A combination of poisons produced by the yew tree. Pacilitaxel prevents prophase from occuring. How does Pacilitaxel specifically inhibit mitosis? By inhibiting microtubules' ability to shrink. What happens to a cell that has been exposed to Pacilitaxel? It undergoes programmed cell death. Study with Quizlet and memorize flashcards containing ...
Biology questions and answers; Read the case study "Who Killed Yew? Murder and Mitosis" and answer the following questions.What is Taxus baccata? Where is it found? Does it have medicinal or traditional uses? What is the purpose of adding the seeds of the plant to the pecans?What is a taxine and how does it disrupt mitosis?Why did Dr ...
Biology questions and answers; a the case study Who Killed Yew? Murder and Mitosis" and answer the following questions. 1. What is Taxus baccata? Where is it found? Does it have medicinal or traditional uses? What is the purpose of adding the seeds of the plant to the pecans? 2. What is a taxine and how does it disrupt mitosis? 3.
Refer to the case study "Who Killed Yew" to answer the following question: Why does ingesting parts of the yew tree cause death while administration of the chemotherapy drug Taxol does not? c. The yew plant contains multiple taxines in addition to paclitaxil, specifically taxine B, which is highly lethal when ingested. QUESTION 6
Yew Case Study work national center for case study teaching in science who killed yew? murder and mitosis marlee marsh department of biology columbia college, ... "Who Killed Y ew?" by M arlee B. Marsh P age 1 . Recommended for you. 3. KEY DNA and DNA Replication Webquest. Biology I 100% (1) 2. 1.03 fitness assessment.
View _Who_Killed_Yew_Case_Study from OCN 101 at Freedom High School. Who Killed Yew - Cell Cycle Case Study Read each section, and answer the corresponding questions. Remember that we have
Study with Quizlet and memorize flashcards containing terms like taxines, mitotic inhibitor, microtubules and more. ... Unit 2: Case Study #1 Who Killed Yew. 10 terms. hayleedawnace. Preview. Cell Basis Exam 1. 97 terms. hannahrmaass. Preview. Photosynthesis and Cellular Respiration. 18 terms. Jomairy5. Preview. Mitosis and Meiosis Overview.
Marlee B. Marsh Department of Biology Columbia College, Columbia, SC. Part I - The Intruder. Th e intruder entered the kitchen of the upscale restaurant at 2:43am. All was quiet. All was dark. Th e intruder moved quickly, but he was not in a rush. He knew that the baker would not arrive until 4:00am, as she did most mornings.
Guests would be poisoned (and probably killed) because the seeds of Taxus baccata are poisoned. By adding them to a pie after eating it guests would feel accelerated heart rate, muscle tremors, convulsions, collapse, difficulty breathing, circulation impairment and eventually cardiac arrest.
NATIONAL CENTER FOR CASE STUDY TEACHING IN SCIENCE Who Killed Yew? Murder and Mitosis by Marlee B. Marsh Department of Biology Columbia College, Columbia, SC Part I - The Intruder e intruder entered the kitchen of the upscale restaurant at 2:43am. All was quiet. All was dark. e intruder moved quickly, but he was not in a rush.
The Mechanics of Murder. Jason Michael McCann. From the Euthanasia Programme to the wholesale and systematic murder of tens of thousands of Hungarian Jews at KZ Auschwitz in 1944, this presentation aims to take a clinical look at the development and deployment of the mechanisms that made murder on such a colossal sale possible.
Study with Quizlet and memorize flashcards containing terms like Case Studies Who Killed Yew Murder and Mitosis, Taxins, Mitotic Inhibitors and more. ... Verified answer. health. Identify each statement as True or False. If false, replace the underlined term with the correct term.
Google doc answer sheet for case study Your textbook is an excellent resource, especially for the role of microtubules, kinetochores, stages of mitosis, cell cycle regulation, cancer, etc.. Pages 85, 174-188. You may use the internet for help as well. "Who Killed Yew?" by Marlee B. Marsh Page "Who Killed Yew? Mitosis and Murder" Case Study Part I - The Intruder Questions
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Wild animal suffering is the suffering experienced by non-human animals living outside of direct human control due to harms, such as disease, injury, parasitism, starvation and malnutrition, dehydration, weather conditions, natural disasters, and killings by other animals, [1] [2] as well as psychological stress. [3] Some estimates indicate that these individual animals make up the vast ...
a. I do not think cancer patients could not be given chemotherapeutic drugs indefinitely. Ingesting parts of the yew tree is dangerous because administration is uncontrolled. In the case of the dinner party, the dose of paclitaxel was greater with the intent to commit murder. The amount ingested has an effect on a patient, which is why Dr. Beckham did not die when she consumed the small amount ...
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