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  • Published: 09 November 2017

Ethical principles for the use of human cellular biotechnologies

  • Paul Root Wolpe 1 ,
  • Karen S Rommelfanger 1 &

the Drafting and Reviewing Delegates of the BEINGS Working Groups

Nature Biotechnology volume  35 ,  pages 1050–1058 ( 2017 ) Cite this article

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  • Biotechnology
  • Cell biology

Recent developments in bioengineering promise the possibility of new diagnostic and treatment strategies, novel industrial processes, and innovative approaches to thorny problems in fields such as nutrition, agriculture, and biomanufacturing. As modern genetics has matured and developed technologies of increasing power, debates over risk assessments and proper applications of the technology, and over who should have decision-making power over such issues, have become more prominent. Recently, some scientists have advocated that ethicists “step out of the way,” whereas others have called for greater ethical scrutiny, or even for moratoria on some lines of research 1 , 2 . As a community, however, we must together determine the proper application of these powerful biological tools. This paper, a consensus statement of a group of interdisciplinary delegates drawn from the top biotech-producing countries of the world, offers a set of ethical principles to contribute to the ethical conversation about human cellular biotechnological research moving forward.

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BEINGS was made possible by grants from the Coca-Cola Foundation, Emory University, The Marcus Foundation, Georgia Research Alliance, Wipro Limited, King & Spalding Law Firm, the Metro Atlanta Chamber of Commerce, Southwest Airlines, Sanofi, Air France, The Embassy of the Republic of France, the Atlanta Clinical and Translational Science Institute, Central Atlanta Progress, and Biofaction. Academic partners included the Georgia Institute of Technology, the University of Georgia, Kennesaw State University, Brenau University, Mercer University, Agnes Scott College, Columbia Theological Seminary, Georgia College, Georgia Gwinnett College, Georgia State University, Morehouse School of Medicine, University of Northern Georgia, Oglethorpe University Savannah College of Art and Design, and the University of West Georgia.

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Paul Root Wolpe and Karen S. Rommelfanger are at the Center for Ethics, Emory University, Atlanta, Georgia, USA.,

Paul Root Wolpe & Karen S Rommelfanger

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Correspondence to Paul Root Wolpe .

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One author, Karol Estrada, reports receiving salary and stocks from Biogen.

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Wolpe, P., Rommelfanger, K. & the Drafting and Reviewing Delegates of the BEINGS Working Groups. Ethical principles for the use of human cellular biotechnologies. Nat Biotechnol 35 , 1050–1058 (2017).

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biotechnological research papers

journal description

Biotechnological Research (ISSN 2395-6763) is an open access international peer reviewed journal. The Journal publishes quarterly (4 times an year) innovative research findings from applied biology fields. Main areas journal focuses: (1) Classical Biotechnology which includes the production of animal, plant and microbial bio-products, production optimization and their applications; (2) Environmental Biotechnology which includes bio remediation, waste management, pollutants, hazards and their remedies; (3) Medical Biotechnology dealing with diseases and their solutions using biotechnological tools, current developments in medical diagnostics like innovative ideas, techniques, instruments and so on; (4) Bioinformatics which use of bioinformatics tools in drug designing, prediction of protein structures, development of new algorithms for innovative tools, databases etc.; (4) Plant Biotechnology: latest developments from plant biology including plant tissue culture, stress resistance, hybridization, improvement of crop variety, genetic variation studies and so on; (5) New Biology including advanced molecular biology, genetic engineering and latest technologies which could be revolutionary in the future.

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The recurrent mutations in Orf7a of SARS-CoV-2 provide a deep understanding of its role in the virus�host interactions. Findings of our study revealed that the predicted epitopes could be promising candidates for a vaccine against COVID-19 infections.....

Pharmacological intervention of various Indian medicinal plants in combating COVID-19 infection

Special emphasis has been given on the antiviral activities of these plants against SARS-CoV-2, highlighting their efficacy as potential drug candidates.

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Toward a Diagnostic Test for Human African Trypanosomaisis

Summary: Human African Trypanosomiasis (HAT), caused by Trypanosoma brucei, T. brucei, disproportionately affects inhabitants of Sub Saharan Africa. T. brucei gambiense and T. brucei rhodesiense are the only strains that produce illness in humans. The purpose of this project is to determine if T. brucei Superoxide Dismutases, TbSODs, can be used as a biomarker for positive diagnosis of HAT. The hypothesis to be tested is if a rat is infected with T. brucei, then it will have traces of tbSOD in its bloodstream because as the rat’s immune system fights T. brucei infection some parasitic cells will lyse excreting many internal proteins including SOD into the bloodstream. Our methodology will consist of developing a modified version of the Villagran et al 2005 protocol whereby a series of blood tests will be performed on infected rats. If the blood tests positive for TbSOD then it is assumed that they have a strain of T. brucei. Finally, after confirming the presence of TbSOD, we will use ELISA to establish a correlation between TbSOD’s level and the degree of progression of the infection.

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Approaches from Resveratrol Activities on Central Nervous System Inflammation

Summary: Neuroinflammation is a common protective mechanism in homeostasis breakdown processes on the central nervous system. The prolongation of this process is responsible for the primary immune response of many neurodegenerative diseases. Understand these mechanisms has brought more effective alternatives to the scientific literature, on development of more effective pharmacological interventions. However, allopathic means of intervention to inflammation are sometimes insufficient to promote a good prognosis and reversal of the inflammatory process. Resveratrol is a polyphenol from the stilbene class, that has shown anti-inflammatory characteristics in several disease study methods, mainly in the ability to generate neuroprotection in neuroinflammatory damage models, reducing the production of pro-inflammatory cytokines and allowing survival, as well. Neuronal regeneration activity also as saw mainly through neurotrophin modulation and antioxidant activity. Resveratrol has shown promise in reversing neuronal death, an important activity in the face of the special needs for new drugs, capable enough to promoting better survival for patients with neurodegenerative diseases. In this review, it’s possible saw that Resveratrol has significant characteristics for future use in the treatment of neurodegenerative diseases.

Detection of Sole and Clonal Aneuploidy in Hematologic Malignant Diseases

Summary: Numerical chromosomal aneuploidy has diagnostic and prognostic value in detection of cancer. Hence, the study was undertaken in leukemic cases in our diagnostic laboratory. Analysis of 211 leukemic blood samples from referral cases of Neuberg Supratech Referral Laboratory (NSRL), Ahmedabad, India, since 2017 to 2019 using WHO protocols for chromosomal study. Detection of 23 cases were obtained (23/ 211: 11%) with this condition. Trisomy 8, 11, 13, 21 and monosomy 7 contributed to 18 cases (18/ 23; 78%) with 5 clonal anomaly (5/23; 22%). Four clonal patients were +8, +21 and +21, XXY and -7 with XY cells. Another karyotype with 48,XY,+8,+19/ 47,XY,+8 was detected which seems to be a new cytogenetic anomaly in the literature causing haematologic neoplasms in this cohort.

A Multi-Level Layout Algorithm for Identifying Highly Interacted Human Protein Complexes and Various Protein Pathways

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Phytochemical and Anti-nutritional potentials of leaves and stem-bark of Cathormion altissimum (Hook.f.) Hutch. & Dandy

Summary: The phytochemical and anti-nutritional constituents of leaves and stem-bark of Cathormion altissimum (Hook.f.) Hutch & Dandy was evaluated. The leaves and stem-bark of Cathormion altissimum used for this study were obtained from several communities in the eight local government area of Bayelsa State, Nigeria. The plant was qualitatively and quantitatively analyzed for some phytochemical and anti-nutrients constituents. The results of quantitative analysis showed that alkaloids, saponins, flavonoids, glycosides, phytate, tannins, oxalate and phenols concentrations were 8.04%, 7.7%, 6.94%, 0.432mg/kg, 0.0917%, 2.684%, 71.0 mg/g and 1002.88 mg/kg, respectively in the leaves, and 3.36%, 5.0%, 3.36%, 0.432mg/kg, 0.0917%, 1.026%, 18.10 mg/g and 62.88 mg/kg, respectively in the stem-bark. The qualitative results showed that saponins in both plant parts was very highly present, flavonoids in leaf and tannins in stem-bark were highly present, while terpenes, steroids, phenol in both plant parts and flavonoids in stem-bark and tannins in leaf were fairly present. The study showed that the leaf and stem-bark of the plant has pharmacological potentials against different diseases. While the phytate and oxalate suggests that the plant could be toxic over a prolonged period of use. As such, there is the need for research to be carried out to evaluate the concentration of the anti-nutrients that could be toxic to humans, and therapeutic properties of both plant parts.

Detection of Hemolytic Activity of Aeromonas sp Isolated from Water Samples of Coastal Area, Kochi

Summary: Aeromonas is a Gram negative rod shaped bacteria that causes gastroenteritis, wound infections and sometimes respiratory diseases. They are frequently isolated from fishes and from water. The aim of this study is to isolate and identify Aeromonas sp from different water samples in and around Kochi. Out 16 different water samples collected of which 7 showed positive for presence of Aeromonas sp. Starch ampicillin agar was used for Aeromonas isolation and the colonies were identified phenotypically and genotypically through biochemical characterization and 16S rRNA amplification respectively. Further hemolytic activity of Aeromonas sp isolates were performed on 5% blood agar plates in which 3 samples showed hemolytic activity. The hyl gene responsible for hemolysis in Aeromonas sp were detected using PCR. These findings show that the Aeromoas sp species isolated from water samples are enterotoxigenic.

Isolation and Identification of a Fungus Infecting Egyptian wheat grains Gamiza11 Triticum aestivum

Summary: The Penicillium species are among the most commonly occurring and economically important members of micro-fungi family. In this study, Molecular identification of fungal isolates were used to group and determine genetic variability of Penicillium isolate from Egyptian Gamiza11 wheat grains Triticum aestivum were obtained from Agricultural Administration in Menouf, Governorate of Menoufia, Egypt. The fungal DNA was then sent to SolGent Company, Daejeon South Korea for polymerase chain reaction (PCR) and gene sequencing. PCR was performed using two universal fungal primers ITS1 (forward) and ITS4 (reverse) which were incorporated in the reaction mixture. Molecular analysis also indicated genotype variability between the isolates with little correlation with either the origin of soil or geographical location.

Heavy Metal Assessment of Unripe Plantain Flour Sold in Some Markets in Osun State, Nigeria

Summary: Heavy metals, such as cadmium, arsenic and lead, are important environmental pollutants, particularly in areas with high anthropogenic pressure. Their presence in the atmosphere, soil and water, even in traces can cause serious problems to all organisms, and heavy metal bioaccumulation in the food chain especially can be highly dangerous to human health. Heavy metals enter the human body mainly through two routes namely: inhalation and ingestion, ingestion being the main route of exposure to these elements in human population. Heavy metals intake by human populations through food chain has been reported in many countries. This research work evaluated the level of heavy metals in plantain flour displayed in open containers for sale in ten locations alongside two packaged brands in Osun State. Heavy metals in the 12 samples were determined using Atomic Absorption Spectrophotometer (AAS).The average concentration for each heavy metal in all the samples ranged between 0 – 120.23 mg/kg for arsenic, 0.50 – 4.51 mg/kg for cadmium and lead was not detected in any of the samples. These findings indicate that foods displayed in open containers in markets or road sides are contaminated by the polluted environments. Excessive consumption can increase the level of heavy metal contamination in the body which may affect the health of the consumers.

Recovery of Agro-based Bio-Products from Cattle Farm Waste Using Aerobic Fluidized Crystallization Reactor

Summary: Plenty of well proven anaerobic methods are in existence to leisurely convert cattle farm waste into useful derivatives such as manure. But, unfortunately, anoxic processes are hectic and quite hard to comply with. Thus, the present study aimed to primarily address highend solutions to overcome the technical drawbacks of the existing anaerobic methods. Nutrients from the cattle farm waste streams were recovered by aerobic treatment mechanism, utilizing fluidized bed reactor (FBR) with dairy and goat manures as feed influents. In order to optimize the recovery, an effective pH value was determined and upheld by using a buffer solution of MgCl2.6H2O and NaOH. The maximum amount of struvites recovered from goat wastes was 93.2% of magnesium, 70.2% of ammonia, and 92.2% of phosphate. While the witnessed recovered fractions were scanty in the case of dairy wastes, which were as follows: 92.2% of magnesium, 68.2% of ammonia, and 91.2% of phosphate. The influence of pH and HRT on the yield of nutrient recovery has played a significant role. The study revealed supplementary recovery was achieved at the optimum condition (i.e., pH 9.0, HRT 2h) when the influent stream was doused with 0.06 M Mg2+. Ultimately, it was concluded that goat manure has a higher capacity of removing the nutrients compared to the dairy manure.


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    GenBank release 260.0 (4/19/2024) is now available on the NCBI FTP site. This release has 31.18 trillion bases and 4.46 billion records. The current release has: 250,803,006 traditional records containing 3,213,818,003,787 base pairs of sequence data 3,333,621,823 WGS records containing 27,225,116,587,937 base pairs of sequence data 741,066,498 ...

  9. An Introduction to Biotechnology

    The biotechnological tools are employed toward modification of the gene for gain of function or loss of function of the protein. The technique of removing, adding, or modifying genes in the genome or chromosomes of an organism to bring about the changes in the protein information is called genetic engineering or recombinant DNA technology (Fig ...

  10. Home

    Research Paper 24 April 2024 Cell line-specific impact of dexamethasone on the bioprocessing of Chinese hamster ovary cells. Yeong Bin An; Da Eun Kang; Jong Kwang Hong; Research Paper 23 April 2024 Study on the S239D/I332E mutation effect on the kinetics of Fc-Fc receptor binding through transition complex theory ...

  11. A brief overview of global biotechnology

    Between 2016 and 2019, the number of businesses involved in biotechnological research increased. In 2019, 1692 people worked in biotechnology activities and the total R&D expenditure in these activities was approximately 325 million TL in the same year. ... A Briefings Paper with Six Proposals Commissioned by UNIDO. 2002; ISSN:1534-6447. Vol ...

  12. Environmental biotechnology

    Environmental biotechnology articles from across Nature Portfolio. Atom; RSS Feed; Definition. Environmental biotechnology is the branch of biotechnology that addresses environmental problems ...

  13. Biotechnology Reports

    Biological and Biotechnological Applications of Natural Bioactives and Biochemicals. Edited by Vijai K. Gupta. 25 July 2022. View all special issues and article collections. View all issues. Read the latest articles of Biotechnology Reports at, Elsevier's leading platform of peer-reviewed scholarly literature.

  14. Emerging biotechnology applications in natural product and synthetic

    The number of papers published in the last 15 years (2007-2022) included in the Web of Science was searched with the keywords "pharmaceutical analysis" combined with "chemical analysis" or "biological analysis". ... Although biotechnological approaches cannot provide chemical information ... This research provides ideas for ...

  15. 362021 PDFs

    Biotechnology | Explore the latest full-text research PDFs, articles, conference papers, preprints and more on BIOTECHNOLOGY. Find methods information, sources, references or conduct a literature ...

  16. Biomedical and Biotechnology Research Journal (BBRJ)

    Distinct Host Gene Targets and Mode of Action in the MicroRNA of Nipah Virus from Malaysia and Bangladesh: A Comparative in-silico Based Analysis. Dsouza, Norine; Gupta, Deepti Bhushan; Chellasamy, Selvaa Kumar. Biomedical and Biotechnology Research Journal. 7 (3):340-350, Jul-Sep 2023. Abstract.

  17. (PDF) Biotechnology

    This paper aims to identify and analyse the key elements that can guarantee a successful project in a biotechnological field, using both the theoretical approach and the author's own expertise in ...

  18. Animal biotechnology

    Animal biotechnology is a branch of biotechnology in which molecular biology techniques are used to genetically engineer (i.e. modify the genome of) animals in order to improve their suitability ...

  19. Biotechnology Research and Innovation

    Strategies for crop improvement under biotic and abiotic stresses. Edited by Alessandra Alves de Souza, Paulo Cavalcanti Gomes Ferreira, Robert Miller. 2019. Read the latest articles of Biotechnology Research and Innovation at, Elsevier's leading platform of peer-reviewed scholarly literature.

  20. Plastic-Eating Microorganisms: Recent Biotechnological Techniques for

    Biotechnological techniques used for the biodegradation of plastics ... 14 research papers, 5 books and 16 book chapters with Springer, 1 practical manual, 33 popular articles, and 2 editorials. ...

  21. Curcumin for Food and Biotechnological Applications

    Curcumin, a yellow polyphenolic pigment from the Curcuma longa L. (turmeric) rhizome, has been used for centuries for culinary and food coloring purposes, and as an ingredient for various medicinal preparations, widely used in Ayurveda and Chinese medicine. In recent decades, their biological activities have been extensively studied. Thus, this review aims to offer an in-depth discussion of ...

  22. Ethical principles for the use of human cellular biotechnologies

    The challenges related to biotechnologies have spawned conferences, white papers, and sets of guidelines, all trying to suggest ways to responsibly contain the power of biotechnologies, such as ...

  23. Biotechnological Research

    Biotechnological Research (ISSN 2395-6763) is an open access international peer reviewed journal. The Journal publishes quarterly (4 times an year) innovative research findings from applied biology fields. Main areas journal focuses: (1) Classical Biotechnology which includes the production of animal, plant and microbial bio-products, production optimization and their applications; (2 ...