Self-selection vs Randomized Assignment of Treatment for Appendicitis
Self-selection vs Randomized Assignment of Treatment for Appendicitis
Self-selection vs Randomized Assignment of Treatment for Appendicitis
Self-selection vs Randomized Assignment of Treatment for Appendicitis
Self-selection vs Randomized Assignment of Treatment for Appendicitis
(PDF) Surgical Treatment Algorithm for Acute Appendicitis
COMMENTS
Self-selection vs Randomized Assignment of Treatment for Appendicitis
Importance: For adults with appendicitis, several randomized clinical trials have demonstrated that antibiotics are an effective alternative to appendectomy. However, it remains unknown how the characteristics of patients in such trials compare with those of patients who select their treatment and whether outcomes differ.
Self-selection vs Randomized Assignment of Treatment for Appendicitis
Self-selection vs Randomized Assignment of Treatment for Appendicitis. Writing Group for the CODA Collaborative. ... 1.07-1.65; OR adjusted for site, 0.96; 95% CI, 0.72-1.28) were associated with cohort (self-selection vs randomized), but those associations were attenuated after adjusting for site. Spanish as primary language, however, was less ...
Self-selection vs Randomized Assignment of Treatment for Appendicitis
The randomized cohort included 1094 adults with appendicitis; the self-selection cohort included patients who declined participation in the randomized group, of whom 253 selected appendectomy and ...
Self-selection vs Randomized Assignment of Treatment for Appendicitis
Self-selection vs Randomized Assignment of Treatment for Appendicitis. Academic Article Overview abstract . Importance: For adults with appendicitis, several randomized clinical trials have demonstrated that antibiotics are an effective alternative to appendectomy.
Treatment for Appendicitis
Self-selection vs Randomized Assignment of Treatment for Appendicitis ... we note that appendicolith was more common in the self-selection appendectomy group than in the self-selection antibiotics group. ... a secondary analysis of a 2011 RCT has shown that appendicolith was the only risk factor for failure of antibiotic treatment in acute ...
Self-selection vs Randomized Assignment of Treatment for Appendicitis
A secondary analysis of the CODA RCT found substantially similar outcomes across the randomized and self-selection cohorts, suggesting that the randomized trial results are generalizable to the community at large. Importance For adults with appendicitis, several randomized clinical trials have demonstrated that antibiotics are an effective alternative to appendectomy. However, it remains ...
The current management of acute uncomplicated appendicitis: should
Appendectomy has long been the mainstay of intervention for acute appendicitis, aiming at preventing perforation, peritonitis, abscess formation and recurrence. With better understanding of the disease process, non-operative management (NOM) with antibiotics alone has been proved a feasible treatment for uncomplicated appendicitis. This article aimed at systematically reviewing the available ...
Antibiotics versus Appendectomy for Acute Appendicitis
Antibiotic treatment of appendicitis is now described as an "accepted first-line treatment" by the American College of Surgeons 1 on the basis of the results of several randomized trials. 2 In ...
Treatment of Acute Uncomplicated Appendicitis
Salminen P, Paajanen H, Rautio T, et al. Antibiotic therapy vs appendectomy for treatment of uncomplicated acute appendicitis: the APPAC randomized clinical trial. JAMA 2015;313:2340-2348. Crossref
PDF Nonoperative Management of Appendicitis in Adults: A Systematic Review
with uncomplicated appendicitis at admission.3 In parallel, there is increasing recognition that the path-ogenesis and natural history of appendicitis is variable. Logically, some patients will have an episode that will not progress or perhaps may even be self-limiting,4 and antibiotics alone will sometimes suffice. Indeed, this
"Self-selection vs Randomized Assignment of Treatment for Appendicitis
Importance: For adults with appendicitis, several randomized clinical trials have demonstrated that antibiotics are an effective alternative to appendectomy. However, it remains unknown how the characteristics of patients in such trials compare with those of patients who select their treatment and whether outcomes differ. Objective: To compare participants in the Comparison of Outcomes of ...
Non-operative treatment versus appendectomy for acute uncomplicated
Acute Appendicitis has an estimated lifetime risk of about 6.7-8.6%.1,2 Though the peak incidence is in second decade, overall, 11.4% children present in the emergency with acute appendicitis.3. The gold standard treatment for appendicitis is considered to be appendectomy.4 Appendectomy is an invasive procedure which leads to disturbance in ...
Randomized Pilot Test of a Decision Support Tool for Acute Appendicitis
Methods: We conducted an online randomized field test in at-risk individuals comparing the decision support tool to a standard infographic. Individuals were randomized 3:1 to view the decision support tool or infographic. The primary outcome was the total decisional conflict scale (DCS) score measured before and after exposure to the decision ...
Self-selection vs Randomized Assignment of Treatment for Appendicitis
The randomized cohort included 1094 adults with appendicitis; the self-selection cohort included patients who declined participation in the randomized group, of whom 253 selected appendectomy and 257 selected antibiotics.
Clinical practice selectively follows acute appendicitis guidelines
Parsons C, Shapiro NI, Cooper R, Tichter A, Fleischman R, Collaborative WG for the C, et al. Self-selection vs randomized assignment of treatment for appendicitis. Jama Surg. 2022;157:598-607. ... Collaborative WG for the C, et al. Patient factors associated with appendectomy within 30 days of initiating antibiotic treatment for appendicitis ...
Comparing Antibiotics versus Surgery for Treating Appendicitis -- The
Self-selection vs Randomized Assignment of Treatment for Appendicitis. ... the outcomes for patients with an appendicolith because these patients are typically excluded from clinical trials on appendicitis treatment. The reviewers questioned the researchers' approach to their power calculations, which seemed to be focused on differences ...
Self-selection vs Randomized Assignment of Treatment for Appendicitis
Findings. In this secondary analysis of the CODA randomized clinical trial (RCT), including 1094 randomized patients and a contemporaneously recruited self-selection cohort consisting of 510 patients who declined randomization, clinical characteristics and most outcomes were similar between RCT participants and those who selected treatment.
Self-selection vs Randomized Assignment of Treatment for Appendicitis
Self-selection vs Randomized Assignment of Treatment for Appendicitis . × Close Log In. Log in with Facebook Log in with Google. or. Email. Password. Remember me on this computer. or reset password. Enter the email address you signed up with and we'll email you a reset link. ... Self-selection vs Randomized Assignment of Treatment for ...
Self-selection vs Randomized Assignment of Treatment for Appendicitis
Self-selection vs Randomized Assignment of Treatment for Appendicitis Writing Group for the CODA Collaborative IMPORTANCE For adults with appendicitis, several randomized clinical trials have demonstrated that antibiotics are an effective alternative to appendectomy. However, it remains unknown how the characteristics of patients in such trials compare with those of patients who select their ...
Self-selection vs Randomized Assignment of Treatment for Appendicitis
JAMA Surg. 2022 May 25. doi: 10.1001/jamasurg.2022.1554. Online ahead of print.ABSTRACTIMPORTANCE: For adults with appendicitis, several randomized clinical trials have demonstrated that antibiotics are an effective alternative to appendectomy. However, it remains unknown how the characteristics of patients in such trials compare with those of patients who select their treatment and whether ...
Self-selection vs Randomized Assignment of Treatment for Appendicitis
Self-selection vs Randomized Assignment of Treatment for Appendicitis. Best source View on content provider's site ...
Treatment for Appendicitis
To the Editor We write regarding the recent article by the Writing Group for the CODA Collaborative, 1 which was discussed in our UK-based online journal club, CRAMSURG. This was an interesting article and led to numerous discussion themes. We would like to congratulate the authors for their efforts in performing both a randomized clinical trial and a parallel cohort study on such a relevant ...
Error in Figure and Results
The Original Investigation titled "Self-selection vs Randomized Assignment of Treatment for Appendicitis," 1 was corrected to fix errors in the Figure title and y-axis label (where "cumulative hazard" had been erroneously written as "cumulative incidence") and the last sentence of the Results (where the data for the RCT and self-selection cohorts had been swapped).
IMAGES
COMMENTS
Importance: For adults with appendicitis, several randomized clinical trials have demonstrated that antibiotics are an effective alternative to appendectomy. However, it remains unknown how the characteristics of patients in such trials compare with those of patients who select their treatment and whether outcomes differ.
Self-selection vs Randomized Assignment of Treatment for Appendicitis. Writing Group for the CODA Collaborative. ... 1.07-1.65; OR adjusted for site, 0.96; 95% CI, 0.72-1.28) were associated with cohort (self-selection vs randomized), but those associations were attenuated after adjusting for site. Spanish as primary language, however, was less ...
The randomized cohort included 1094 adults with appendicitis; the self-selection cohort included patients who declined participation in the randomized group, of whom 253 selected appendectomy and ...
Self-selection vs Randomized Assignment of Treatment for Appendicitis. Academic Article Overview abstract . Importance: For adults with appendicitis, several randomized clinical trials have demonstrated that antibiotics are an effective alternative to appendectomy.
Self-selection vs Randomized Assignment of Treatment for Appendicitis ... we note that appendicolith was more common in the self-selection appendectomy group than in the self-selection antibiotics group. ... a secondary analysis of a 2011 RCT has shown that appendicolith was the only risk factor for failure of antibiotic treatment in acute ...
A secondary analysis of the CODA RCT found substantially similar outcomes across the randomized and self-selection cohorts, suggesting that the randomized trial results are generalizable to the community at large. Importance For adults with appendicitis, several randomized clinical trials have demonstrated that antibiotics are an effective alternative to appendectomy. However, it remains ...
Appendectomy has long been the mainstay of intervention for acute appendicitis, aiming at preventing perforation, peritonitis, abscess formation and recurrence. With better understanding of the disease process, non-operative management (NOM) with antibiotics alone has been proved a feasible treatment for uncomplicated appendicitis. This article aimed at systematically reviewing the available ...
Antibiotic treatment of appendicitis is now described as an "accepted first-line treatment" by the American College of Surgeons 1 on the basis of the results of several randomized trials. 2 In ...
Salminen P, Paajanen H, Rautio T, et al. Antibiotic therapy vs appendectomy for treatment of uncomplicated acute appendicitis: the APPAC randomized clinical trial. JAMA 2015;313:2340-2348. Crossref
with uncomplicated appendicitis at admission.3 In parallel, there is increasing recognition that the path-ogenesis and natural history of appendicitis is variable. Logically, some patients will have an episode that will not progress or perhaps may even be self-limiting,4 and antibiotics alone will sometimes suffice. Indeed, this
Importance: For adults with appendicitis, several randomized clinical trials have demonstrated that antibiotics are an effective alternative to appendectomy. However, it remains unknown how the characteristics of patients in such trials compare with those of patients who select their treatment and whether outcomes differ. Objective: To compare participants in the Comparison of Outcomes of ...
Acute Appendicitis has an estimated lifetime risk of about 6.7-8.6%.1,2 Though the peak incidence is in second decade, overall, 11.4% children present in the emergency with acute appendicitis.3. The gold standard treatment for appendicitis is considered to be appendectomy.4 Appendectomy is an invasive procedure which leads to disturbance in ...
Methods: We conducted an online randomized field test in at-risk individuals comparing the decision support tool to a standard infographic. Individuals were randomized 3:1 to view the decision support tool or infographic. The primary outcome was the total decisional conflict scale (DCS) score measured before and after exposure to the decision ...
The randomized cohort included 1094 adults with appendicitis; the self-selection cohort included patients who declined participation in the randomized group, of whom 253 selected appendectomy and 257 selected antibiotics.
Parsons C, Shapiro NI, Cooper R, Tichter A, Fleischman R, Collaborative WG for the C, et al. Self-selection vs randomized assignment of treatment for appendicitis. Jama Surg. 2022;157:598-607. ... Collaborative WG for the C, et al. Patient factors associated with appendectomy within 30 days of initiating antibiotic treatment for appendicitis ...
Self-selection vs Randomized Assignment of Treatment for Appendicitis. ... the outcomes for patients with an appendicolith because these patients are typically excluded from clinical trials on appendicitis treatment. The reviewers questioned the researchers' approach to their power calculations, which seemed to be focused on differences ...
Findings. In this secondary analysis of the CODA randomized clinical trial (RCT), including 1094 randomized patients and a contemporaneously recruited self-selection cohort consisting of 510 patients who declined randomization, clinical characteristics and most outcomes were similar between RCT participants and those who selected treatment.
Self-selection vs Randomized Assignment of Treatment for Appendicitis . × Close Log In. Log in with Facebook Log in with Google. or. Email. Password. Remember me on this computer. or reset password. Enter the email address you signed up with and we'll email you a reset link. ... Self-selection vs Randomized Assignment of Treatment for ...
Self-selection vs Randomized Assignment of Treatment for Appendicitis Writing Group for the CODA Collaborative IMPORTANCE For adults with appendicitis, several randomized clinical trials have demonstrated that antibiotics are an effective alternative to appendectomy. However, it remains unknown how the characteristics of patients in such trials compare with those of patients who select their ...
JAMA Surg. 2022 May 25. doi: 10.1001/jamasurg.2022.1554. Online ahead of print.ABSTRACTIMPORTANCE: For adults with appendicitis, several randomized clinical trials have demonstrated that antibiotics are an effective alternative to appendectomy. However, it remains unknown how the characteristics of patients in such trials compare with those of patients who select their treatment and whether ...
Self-selection vs Randomized Assignment of Treatment for Appendicitis. Best source View on content provider's site ...
To the Editor We write regarding the recent article by the Writing Group for the CODA Collaborative, 1 which was discussed in our UK-based online journal club, CRAMSURG. This was an interesting article and led to numerous discussion themes. We would like to congratulate the authors for their efforts in performing both a randomized clinical trial and a parallel cohort study on such a relevant ...
The Original Investigation titled "Self-selection vs Randomized Assignment of Treatment for Appendicitis," 1 was corrected to fix errors in the Figure title and y-axis label (where "cumulative hazard" had been erroneously written as "cumulative incidence") and the last sentence of the Results (where the data for the RCT and self-selection cohorts had been swapped).